Abstract
Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain α-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek's disease virus (MDV), Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate.
| Original language | English |
|---|---|
| Article number | 757 |
| Journal | Viruses |
| Volume | 12 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2020 |
Bibliographical note
Funding Information:Funding: This work was supported by Canadian Institutes for Health Research Operating Grant MOP-84554.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
ASJC Scopus Subject Areas
- Infectious Diseases
- Virology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
