TY - JOUR
T1 - The C/EBP-Binding Region and Adjacent Sites Regulate Expression of the Adipose P2 Gene in Human Preadipocytes
AU - Ro, Hyo Sung
AU - Roncari, Daniel A.K.
PY - 1991/4
Y1 - 1991/4
N2 - Human preadipocytes contain nuclear factors that specifically bind to the AE-1 sequence, previously demonstrated as an enhancer element in the regulation of adipose P2 gene expression during 3T3 adipose differentiation. By transient transfection and in vivo competition experiments, the trans-acting factors were found to bind either to the C/EBP recognition site in the AE-1 sequence and act as a negative regulator or to the adjacent site (termed 3′ AE-1) and act as a positive regulator of adipose P2 gene activity in human preadipocytes.
AB - Human preadipocytes contain nuclear factors that specifically bind to the AE-1 sequence, previously demonstrated as an enhancer element in the regulation of adipose P2 gene expression during 3T3 adipose differentiation. By transient transfection and in vivo competition experiments, the trans-acting factors were found to bind either to the C/EBP recognition site in the AE-1 sequence and act as a negative regulator or to the adjacent site (termed 3′ AE-1) and act as a positive regulator of adipose P2 gene activity in human preadipocytes.
UR - http://www.scopus.com/inward/record.url?scp=0026061257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026061257&partnerID=8YFLogxK
U2 - 10.1128/MCB.11.4.2303
DO - 10.1128/MCB.11.4.2303
M3 - Article
C2 - 2005913
AN - SCOPUS:0026061257
SN - 0270-7306
VL - 11
SP - 2303
EP - 2306
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 4
ER -