The C/EBP-Binding Region and Adjacent Sites Regulate Expression of the Adipose P2 Gene in Human Preadipocytes

Hyo Sung Ro, Daniel A.K. Roncari

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Human preadipocytes contain nuclear factors that specifically bind to the AE-1 sequence, previously demonstrated as an enhancer element in the regulation of adipose P2 gene expression during 3T3 adipose differentiation. By transient transfection and in vivo competition experiments, the trans-acting factors were found to bind either to the C/EBP recognition site in the AE-1 sequence and act as a negative regulator or to the adjacent site (termed 3′ AE-1) and act as a positive regulator of adipose P2 gene activity in human preadipocytes.

Original languageEnglish
Pages (from-to)2303-2306
Number of pages4
JournalMolecular and Cellular Biology
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1991

ASJC Scopus Subject Areas

  • Molecular Biology
  • Cell Biology

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