The effect of carbonic anhydrase inhibition on the canine in vivo H+PCO2 relationship

D. T. Zborowska-Sluis; D. P. Tozzi; G. A. Klassen

doi:10.1016/0034-5687(72)90066-7

The effect of carbonic anhydrase inhibition on the canine in vivo H⁺P_CO₂ relationship

D. T. Zborowska-Sluis, D. P. Tozzi, G. A. Klassen

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The in vivo canine H⁺ -P_CO₂ relationship was measured in muscle venous, pulmonary arterial, and arterial blood, at a range of P_CO₂ values during hyperventilation, before and following acetazolamide. An increase in slope of the straight line describing this relationship was detected from the muscle venous to the arterial sampling site. Following acetazolamide the muscle venous and pulmonary arterial lines had a similar slope to the unchanged arterial line. The response of the venous lines suggests that carbonic anhydrase plays a significant role in determining the effective _{in vivo} buffering of the venous compartment.

Original language	English
Pages (from-to)	377-385
Number of pages	9
Journal	Respiration Physiology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(72)90066-7
Publication status	Published - Dec 1972
Externally published	Yes

Bibliographical note

Funding Information:
1 This investigation was supported by grants from the Medical Research Council of Canada, and the Muscular Dystrophy Association of Canada. * Supported by a student fellowship from the Quebec Research Council.

ASJC Scopus Subject Areas

Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/0034-5687(72)90066-7

Cite this

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title = "The effect of carbonic anhydrase inhibition on the canine in vivo H+PCO2 relationship",

abstract = "The in vivo canine H+ -PCO2 relationship was measured in muscle venous, pulmonary arterial, and arterial blood, at a range of PCO2 values during hyperventilation, before and following acetazolamide. An increase in slope of the straight line describing this relationship was detected from the muscle venous to the arterial sampling site. Following acetazolamide the muscle venous and pulmonary arterial lines had a similar slope to the unchanged arterial line. The response of the venous lines suggests that carbonic anhydrase plays a significant role in determining the effective in vivo buffering of the venous compartment.",

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