The effect of umbilical cord milking on cerebral blood flow in very preterm infants: a randomized controlled study

Walid El-Naggar; Douglas McMillan; Arif Hussain; Anthony Armson; Andrew Warren; Robin Whyte; David Simpson

doi:10.1038/s41372-020-00780-2

The effect of umbilical cord milking on cerebral blood flow in very preterm infants: a randomized controlled study

Walid El-Naggar, Douglas McMillan, Arif Hussain, Anthony Armson, Andrew Warren, Robin Whyte, David Simpson

Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objective: To compare the effect of umbilical cord milking (UCM) vs. early cord clamping (ECC) on cerebral blood flow (CBF). Method: Preterm infants <31 weeks’ gestation were randomized to receive UCM or ECC at birth. Blood flow velocities and resistive & pulsatility indices of middle and anterior cerebral arteries were measured at 4–6 and 10–12 h after birth as an estimate of CBF. Results: Randomization allocated 37 infants to UCM and 36 to ECC. Maternal and antenatal variables were similar. There were no significant differences between groups in middle or anterior CBF velocities and resistive indices at either study time point. CBF variables were not correlated with mean blood pressure, systemic blood flow, or intraventricular hemorrhage. Conclusions: In very preterm infants, UCM compared with ECC was not shown to change CBF indices during the first 12 h of age or correlate with other hemodynamic measures or with intraventricular hemorrhage. Trial registration: ClinicalTrials.gov: NCT01487187.

Original language	English
Pages (from-to)	263-268
Number of pages	6
Journal	Journal of Perinatology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1038/s41372-020-00780-2
Publication status	Published - Feb 2021

Bibliographical note

Funding Information:
Funding This project was supported by grants from both Nova Scotia Health Research Foundation (PSO-EST-2013-9023 EGMS 1813) and IWK Research Foundation (1008052). No honorarium or other form of payment was given to anyone to produce this manuscript.

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

PubMed: MeSH publication types

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

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abstract = "Objective: To compare the effect of umbilical cord milking (UCM) vs. early cord clamping (ECC) on cerebral blood flow (CBF). Method: Preterm infants <31 weeks{\textquoteright} gestation were randomized to receive UCM or ECC at birth. Blood flow velocities and resistive & pulsatility indices of middle and anterior cerebral arteries were measured at 4–6 and 10–12 h after birth as an estimate of CBF. Results: Randomization allocated 37 infants to UCM and 36 to ECC. Maternal and antenatal variables were similar. There were no significant differences between groups in middle or anterior CBF velocities and resistive indices at either study time point. CBF variables were not correlated with mean blood pressure, systemic blood flow, or intraventricular hemorrhage. Conclusions: In very preterm infants, UCM compared with ECC was not shown to change CBF indices during the first 12 h of age or correlate with other hemodynamic measures or with intraventricular hemorrhage. Trial registration: ClinicalTrials.gov: NCT01487187.",

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note = "Funding Information: Funding This project was supported by grants from both Nova Scotia Health Research Foundation (PSO-EST-2013-9023 EGMS 1813) and IWK Research Foundation (1008052). No honorarium or other form of payment was given to anyone to produce this manuscript. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",

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AU - Armson, Anthony

AU - Warren, Andrew

AU - Whyte, Robin

AU - Simpson, David

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The effect of umbilical cord milking on cerebral blood flow in very preterm infants: a randomized controlled study

Abstract

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ASJC Scopus Subject Areas

PubMed: MeSH publication types

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