The emergence and establishment of a clonal subline with partial duplication of chromosome 1q from a tumorigenic human chronic lymphocytic leukemic B-cell line

Christine L.Y. Lee; Tarunendu Ghose; Louis A. Fernandez; Spencer H.S. Lee

doi:10.1016/0165-4608(88)90060-X

The emergence and establishment of a clonal subline with partial duplication of chromosome 1q from a tumorigenic human chronic lymphocytic leukemic B-cell line

Christine L.Y. Lee, Tarunendu Ghose, Louis A. Fernandez, Spencer H.S. Lee

Medicine

Medicine

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Abstract

Sequential analysis was performed on a tumorigenic human B-cell chronic lymphocytic leukemia cell line in which the initial population consisted of two abnormal clones, one with trisomy 12 (47%), the other with duplication of 1q; that is, 46,XY,dup(1)(q11→q32) (10%), and rest of the population had a normal karyotype. The clone with 1q+ marker expanded steadily and after 11 weeks became the only proliferating cell population in vitro and remained so till the end of an observation period of 75 weeks. All tumors recovered from nude mice that were inoculated with this newly established subline had retained the 1q+ marker. All the secondary clones also carried this aberration.

Original language	English
Pages (from-to)	139-143
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(88)90060-X
Publication status	Published - Jul 1 1988

Bibliographical note

Funding Information:
This investigatiowna s supportedb y the Medical ResearchC ouncil( Canada)G rantsM A9725 and MAIO008. We are gratefutl o P. Colp for her excellentte chnicahl elp and H. Maxnerf or typingt hemanuscript.

ASJC Scopus Subject Areas

Molecular Biology
Genetics
Cancer Research

PubMed: MeSH publication types

Journal Article
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10.1016/0165-4608(88)90060-X

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The emergence and establishment of a clonal subline with partial duplication of chromosome 1q from a tumorigenic human chronic lymphocytic leukemic B-cell line. / Lee, Christine L.Y.; Ghose, Tarunendu; Fernandez, Louis A. et al.
In: Cancer Genetics and Cytogenetics, Vol. 33, No. 1, 01.07.1988, p. 139-143.

Research output: Contribution to journal › Article › peer-review

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AU - Lee, Spencer H.S.

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The emergence and establishment of a clonal subline with partial duplication of chromosome 1q from a tumorigenic human chronic lymphocytic leukemic B-cell line

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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