The functional nucleus

David P. Bazett-Jones; Graham Dellaire

doi:10.1007/978-3-319-38882-3

The functional nucleus

David P. Bazett-Jones, Graham Dellaire

Research output: Book/Report › Book

4 Citations (Scopus)

Abstract

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

Original language	English
Publisher	Springer International Publishing
Number of pages	513
ISBN (Electronic)	9783319388823
ISBN (Print)	9783319388809
DOIs	https://doi.org/10.1007/978-3-319-38882-3
Publication status	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2016.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-38882-3

Cite this

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The functional nucleus

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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