The HIV glycoproteins gp41 and gp120 cause rapid excitation in rat cortical slices

Yushan S. Wang; Thomas D. White

doi:10.1016/S0304-3940(00)01385-9

The HIV glycoproteins gp41 and gp120 cause rapid excitation in rat cortical slices

Yushan S. Wang, Thomas D. White

Medicine

Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Inflammation and associated excitotoxicity may play important roles in various neurodegenerative diseases including AIDS dementia. Here we show that exposure of rat parietal cortical slices to the HIV glycoproteins gp120 and gp41 triggered very rapid releases of the neurotransmitters glutamate and [³H]noradrenaline (NA), and of the neuromodulator adenosine. Gp41 was more effective than gp120 at releasing glutamate and [³H]NA, while both glycoproteins were equi-effective at releasing adenosine. The responses to gp120 and gp41 declined rapidly to basal levels following their removal. It seems possible that rapid, inappropriate excitation may occur in the immediate vicinity of HIV infections in the brain, possibly producing some of the transient neurological and psychiatric symptoms associated with AIDS dementia. (C) 2000 Published by Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Neuroscience Letters
Volume	291
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(00)01385-9
Publication status	Published - Sept 8 2000

Bibliographical note

Funding Information:
The authors wish to thank Ms Zaiping Liu for her excellent technical assistance. This research was supported by a grant to T.D.W. from the MRC of Canada. Y.S.W. is a Killam Scholar.

ASJC Scopus Subject Areas

General Neuroscience

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/S0304-3940(00)01385-9

Cite this

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abstract = "Inflammation and associated excitotoxicity may play important roles in various neurodegenerative diseases including AIDS dementia. Here we show that exposure of rat parietal cortical slices to the HIV glycoproteins gp120 and gp41 triggered very rapid releases of the neurotransmitters glutamate and [3H]noradrenaline (NA), and of the neuromodulator adenosine. Gp41 was more effective than gp120 at releasing glutamate and [3H]NA, while both glycoproteins were equi-effective at releasing adenosine. The responses to gp120 and gp41 declined rapidly to basal levels following their removal. It seems possible that rapid, inappropriate excitation may occur in the immediate vicinity of HIV infections in the brain, possibly producing some of the transient neurological and psychiatric symptoms associated with AIDS dementia. (C) 2000 Published by Elsevier Science Ireland Ltd.",

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AU - Wang, Yushan S.

AU - White, Thomas D.

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AB - Inflammation and associated excitotoxicity may play important roles in various neurodegenerative diseases including AIDS dementia. Here we show that exposure of rat parietal cortical slices to the HIV glycoproteins gp120 and gp41 triggered very rapid releases of the neurotransmitters glutamate and [3H]noradrenaline (NA), and of the neuromodulator adenosine. Gp41 was more effective than gp120 at releasing glutamate and [3H]NA, while both glycoproteins were equi-effective at releasing adenosine. The responses to gp120 and gp41 declined rapidly to basal levels following their removal. It seems possible that rapid, inappropriate excitation may occur in the immediate vicinity of HIV infections in the brain, possibly producing some of the transient neurological and psychiatric symptoms associated with AIDS dementia. (C) 2000 Published by Elsevier Science Ireland Ltd.

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The HIV glycoproteins gp41 and gp120 cause rapid excitation in rat cortical slices

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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