The pattern of radiation-induced transmissible aberrations in a human cell culture

C. L.Y. Lee; O. P. Kamra

doi:10.1007/BF00281689

The pattern of radiation-induced transmissible aberrations in a human cell culture

C. L.Y. Lee, O. P. Kamra

Medicine

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29 Citations (Scopus)

Abstract

The G-band pattern in 445 metaphases obtained seven weeks after irradiation (600 rad gamma-ray) was analysed. Approximately 37% of these cells had one or more structural aberrations. The majority of the aberrant events was reciprocal translocation followed by inversion and deletion in the proportion of 9:1:1 respectively. Statistical analyses (Chi-square tests) on the distribution of breakpoints among chromosomes showed an excess number of breaks in chromosomes 1,7,and 12. Chromosomes 1 and 12 were particularly involved in cells carrying multiple aberrations while chromosome 7 was preferentially involved in deletion. Within chromosomes a significantly large number of breaks were located in(a) the light bands and (b) the terminal segments. The significance of these findings is discussed.

Original language	English
Pages (from-to)	380-384
Number of pages	5
Journal	Human Genetics
Volume	57
Issue number	4
DOIs	https://doi.org/10.1007/BF00281689
Publication status	Published - Jul 1981

ASJC Scopus Subject Areas

Genetics
Genetics(clinical)

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Lee, C. L. Y., & Kamra, O. P. (1981). The pattern of radiation-induced transmissible aberrations in a human cell culture. Human Genetics, 57(4), 380-384. https://doi.org/10.1007/BF00281689

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The pattern of radiation-induced transmissible aberrations in a human cell culture

Abstract

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