Abstract
Peroxisomes are essential metabolic organelles, well known for their roles in the metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes have also been cast as central regulators of immunity. Lipid metabolites of peroxisomes, such as polyunsaturated fatty acids (PUFAs), are precursors for important immune mediators, including leukotrienes (LTs) and resolvins. Peroxisomal redox metabolism modulates cellular immune signaling such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Additionally, peroxisomal β-oxidation and ether lipid synthesis control the development and aspects of the activation of both innate and adaptive immune cells. Finally, peroxisome number and metabolic activity have been linked to inflammatory diseases. These discoveries have opened avenues of investigation aimed at targeting peroxisomes for therapeutic intervention in immune disorders, inflammation, and cancer.
Original language | English |
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Journal | Trends in Cell Biology |
DOIs | |
Publication status | Accepted/In press - 2022 |
Bibliographical note
Funding Information:This work was supported by Project Grant PJT-169179 from the Canadian Institutes of Health Research (CIHR), Discovery Grant RGPIN/04083-2019 from the Natural Sciences and Engineering Research Council of Canada (NSERC), Research Nova Scotia Establishment Grant MED-EST-2019-2144, and a Dalhousie Medical Research Foundation Start-up grant to F.D.C.; CIHR Foundation Grant FDN-143289 to R.A.R.; NSERC Discovery Grant RGPIN-2020-05865 to P.K.; New Frontiers Research Funds-Exploration grant NFRF-E 19-00007 to S.S. and F.D.C.; the regional council of Bourgogne Franche-Comté and the Ministère de l'Education Nationale et de l'Enseignement Supérieur et de la Recherche (France) to S.S.; Swiss Cancer Research grant KFS-4735-02-2019 and Swiss National Science Foundation grant No. 310030_192614 to W.J.K.
Publisher Copyright:
© 2022 Elsevier Ltd
ASJC Scopus Subject Areas
- Cell Biology
PubMed: MeSH publication types
- Journal Article
- Review