The pesticide adjuvant, Toximul™, alters hepatic metabolism through effects on downstream targets of PPARα

Jacqueline Upham, Philip D. Acott, Patrick O'Regan, Christopher J. Sinal, John F.S. Crocker, Laurette Geldenhuys, Mary G. Murphy

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Previous studies demonstrated that chronic dermal exposure to the pesticide adjuvant (surfactant), Toximul™ (Tox), has significant detrimental effects on hepatic lipid metabolism. This study demonstrated that young mice dermally exposed to Tox for 12 days have significant increases in expression of peroxisomal acyl-CoA oxidase (mRNA and protein), bifunctional enzyme (mRNA) and thiolase (mRNA), as well as the P450 oxidizing enzymes Cyp4A10 and Cyp4A14 (mRNA and protein). Tox produced a similar pattern of increases in wild type adult female mice but did not induce these responses in PPARα-null mice. These data support the hypothesis that Tox, a heterogeneous blend of nonionic and anionic surfactants, modulates hepatic metabolism at least in part through activation of PPARα. Notably, all three groups of Tox-treated mice had increased relative liver weights due to significant accumulation of lipid. This could be endogenous in nature and/or a component(s) of Tox or a metabolite thereof. The ability of Tox and other hydrocarbon pollutants to induce fatty liver despite being PPARα agonists indicates a novel consequence of exposure to this class of chemicals, and may provide a new understanding of fatty liver in populations with industrial exposure.

Original languageEnglish
Pages (from-to)1057-1064
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1772
Issue number9
DOIs
Publication statusPublished - Sept 2007

Bibliographical note

Funding Information:
This study was supported by the Natural Sciences and Engineering Research Council of Canada.

ASJC Scopus Subject Areas

  • Molecular Medicine
  • Molecular Biology

PubMed: MeSH publication types

  • Evaluation Study
  • Journal Article
  • Research Support, Non-U.S. Gov't

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