The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena

Margaret M. Kopaniak; Andrew C. Issekutz; Clement E. Burrowes; Henry Z. Movat

doi:10.3181/00379727-163-40733

The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena

Margaret M. Kopaniak, Andrew C. Issekutz, Clement E. Burrowes, Henry Z. Movat

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Cutaneous hemorrhage was quantitated using ⁵⁹Fe-labeled red blood cells. The red blood cells were labeled by injecting ⁵⁹Fe-ferrous citrate, preincubated with serum. Skin lesions were induced either in rabbits whose own red cells had been labeled or in animals which had been transfused with labeled cells. Hemorrhagic lesions were produced by injecting heat- or formalin-killed E. coli, lysates of human PMN-leukocyte lysosomes, trypsin or by eliciting the local Schwartzman reaction.

Original language	English
Pages (from-to)	126-131
Number of pages	6
Journal	Experimental Biology and Medicine
Volume	163
Issue number	1
DOIs	https://doi.org/10.3181/00379727-163-40733
Publication status	Published - Jan 1980
Externally published	Yes

Bibliographical note

Funding Information:
Supported by Grant T. 1-15 from the Ontario Heart Foundation. 2

Funding Information:
Graduate student supported by the Medical Research Council of Canada. 3

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

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title = "The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena",

abstract = "Cutaneous hemorrhage was quantitated using 59Fe-labeled red blood cells. The red blood cells were labeled by injecting 59Fe-ferrous citrate, preincubated with serum. Skin lesions were induced either in rabbits whose own red cells had been labeled or in animals which had been transfused with labeled cells. Hemorrhagic lesions were produced by injecting heat- or formalin-killed E. coli, lysates of human PMN-leukocyte lysosomes, trypsin or by eliciting the local Schwartzman reaction.",

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note = "Funding Information: Supported by Grant T. 1-15 from the Ontario Heart Foundation. 2 Funding Information: Graduate student supported by the Medical Research Council of Canada. 3 ",

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AU - Issekutz, Andrew C.

AU - Burrowes, Clement E.

AU - Movat, Henry Z.

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AB - Cutaneous hemorrhage was quantitated using 59Fe-labeled red blood cells. The red blood cells were labeled by injecting 59Fe-ferrous citrate, preincubated with serum. Skin lesions were induced either in rabbits whose own red cells had been labeled or in animals which had been transfused with labeled cells. Hemorrhagic lesions were produced by injecting heat- or formalin-killed E. coli, lysates of human PMN-leukocyte lysosomes, trypsin or by eliciting the local Schwartzman reaction.

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The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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