Abstract
Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.
| Original language | English |
|---|---|
| Pages (from-to) | 3647-3657 |
| Number of pages | 11 |
| Journal | Biological Trace Element Research |
| Volume | 199 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2021 |
| Externally published | Yes |
Bibliographical note
Funding Information:Open access funding provided by Università degli Studi di Cagliari within the CRUI-CARE Agreement.
Funding Information:
Open access funding provided by Universit? degli Studi di Cagliari within the CRUI-CARE Agreement.
Publisher Copyright:
© 2020, The Author(s).
ASJC Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Clinical Biochemistry
- Inorganic Chemistry
- Biochemistry, medical
PubMed: MeSH publication types
- Journal Article
- Review
