The suppressive effect of interferon on the ability of mouse spleen cells synthesizing IgE to sensitize rat skin for heterologous adoptive cutaneous anaphylaxis

J. Ngan, S. H.S. Lee, L. S. Kind

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release.

Original languageEnglish
Pages (from-to)1063-1066
Number of pages4
JournalJournal of Immunology
Volume117
Issue number4
Publication statusPublished - 1976

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

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Ngan, J., Lee, S. H. S., & Kind, L. S. (1976). The suppressive effect of interferon on the ability of mouse spleen cells synthesizing IgE to sensitize rat skin for heterologous adoptive cutaneous anaphylaxis. Journal of Immunology, 117(4), 1063-1066.