The Use of Immunoglobulin Therapy for Patients Undergoing Solid Organ Transplantation: An Evidence-Based Practice Guideline

Nadine Shehata, Valerie A. Palda, Ralph M. Meyer, Tom D. Blydt-Hansen, Patricia Campbell, Carl Cardella, Steven Martin, Peter Nickerson, Kevork Peltekian, Heather Ross, Tom K. Waddell, Lori West, David Anderson, John Freedman, Heather Hume

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

This guideline for the use of immunoglobulin (IG) for sensitized patients undergoing solid organ transplantation (SOT) is an initiative of the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products of Canada to (1) provide guidance for Canadian practitioners involved in the care of patients undergoing SOT and transfusion medicine specialists on the use of IG and (2) standardize care, limit adverse events, and optimize patient care. A systematic expert and bibliography literature search up to July 2008 was conducted, with 791 literature citations and 45 reports reviewed. To validate the recommendations, the guideline was sent to physicians involved in SOT in Canada and a patient representative. The recommendations identify (1) sensitized patients undergoing SOT that would have a better survival and decreased morbidity by receiving IG preoperatively, postoperatively, and for the treatment of organ rejection; (2) patients who may not have any benefit from receiving IG; and (3) potential adversities to IG.

Original languageEnglish
Pages (from-to)S7-S27
JournalTransfusion Medicine Reviews
Volume24
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2010

Bibliographical note

Funding Information:
STATEMENT OF CONFLICT OF INTEREST: Dr L West receives research funding from the US National Institutes of Health (Grant P01-HL079067). Drs Nadine Shehata and Peter Nickerson are employees of Canadian Blood Services, as were Drs Heather Hume and John Freedman during the period of the development of these guidelines. Funding was provided from an unrestricted education grant from Bayer, Inc, to Canadian Blood Services. Bayer did not have any role in the selection of panel members, the literature search, the selection of articles, or the development of the recommendations.

ASJC Scopus Subject Areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical

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