The use of 3h serotonin release from mast cells of the mouse as an assay for mediator liberation

J. A. Otsuki, R. Grassick, D. Seymour, L. S. Kind

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The release of 3H 5-HT from murine mast cells is shown to be a simple reproducible method for studying the activation of such cells by various agents. 3H-serotonin was taken up by peritoneal cell suspensions in vitro and was released by antigen, Concanavalin A, Forssman antiserum, anti-mouse immunoglobulin, or a polypeptide antibiotic, Cinnamycin.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalImmunological Investigations
Volume5
Issue number1-2
DOIs
Publication statusPublished - 1976

ASJC Scopus Subject Areas

  • Immunology

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