The Wiskott-Aldrich syndrome: refinement of the localization on Xp and identification of another closely linked marker locus, OATL1

Wenda L. Greer, Monica Peacocke, Katherine A. Siminovitch

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20 Citations (Scopus)

Abstract

The Wiskott-Aldrich syndrome (WAS) has previously been mapped to the proximal short arm of the X chromosome between the DXS14 and DXS7 loci. In this study, further segregation analysis has been performed using a newly identified WAS family as well as an additional marker probe, HOATL1. The results indicate close linkage between the WAS and OATL1 loci ( {Mathematical expression}=6.08 at {Mathematical expression}=0.00) and localize the TIMP, OATL1, DXS255, and WAS loci distal to DXS146 and the OATL1 and WAS loci proximal to TIMP. These linkage data narrow the boundaries within which the WAS locus maps to the chromosomal region bracketed by TIMP and DXS146 and support the loci order Xpter-DXS7-TIMP-(OATL1, WAS, DXS255)-DXS146.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalHuman Genetics
Volume88
Issue number4
DOIs
Publication statusPublished - Feb 1992
Externally publishedYes

ASJC Scopus Subject Areas

  • Genetics
  • Genetics(clinical)

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