Abstract
Efficient viral gene expression is threatened by cellular stress response programmes that rapidly reprioritize the translation machinery in response to varied environmental assaults, including virus infection. This results in inhibition of bulk synthesis of housekeeping proteins and causes the aggregation of messenger ribonucleoprotein complexes into cytoplasmic foci that are known as stress granules, which can entrap viral mRNAs. There is accumulating evidence for the antiviral nature of stress granules, which is supported by the discovery of many viral factors that interfere with stress granule formation and/or function. This Review focuses on recent advances in our understanding of the role of translation inhibition and stress granules in antiviral immune responses.
| Original language | English |
|---|---|
| Pages (from-to) | 647-660 |
| Number of pages | 14 |
| Journal | Nature Reviews Immunology |
| Volume | 17 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2017 |
Bibliographical note
Funding Information:This work was supported by grants to C.M. from the Natural Sciences and Engineering Research Council of Canada (RGPIN-341940) and the Canadian Institutes of Health Research (MOP-136817 and PJT-148727). The authors thank members of the McCormick laboratory for providing feedback on the manuscript.
Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
ASJC Scopus Subject Areas
- Immunology and Allergy
- Immunology