Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder

Aja Neergaard Greve; Jens Richardt Møllegaard Jepsen; Erik Lykke Mortensen; Rudolf Uher; Lynn Mackenzie; Leslie Foldager; Ditte Gantriis; Birgitte Klee Burton; Ditte Ellersgaard; Camilla Jerlang Christiani; Katrine S. Spang; Nicoline Hemager; Jamal Uddin; Maria Toft Henriksen; Kate Kold Zahle; Henriette Stadsgaard; Kerstin J. Plessen; Anne A.E. Thorup; Merete Nordentoft; Ole Mors; Vibeke Bliksted

doi:10.1016/j.schres.2022.06.032

Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder

Aja Neergaard Greve, Jens Richardt Møllegaard Jepsen, Erik Lykke Mortensen, Rudolf Uher, Lynn Mackenzie, Leslie Foldager, Ditte Gantriis, Birgitte Klee Burton, Ditte Ellersgaard, Camilla Jerlang Christiani, Katrine S. Spang, Nicoline Hemager, Jamal Uddin, Maria Toft Henriksen, Kate Kold Zahle, Henriette Stadsgaard, Kerstin J. Plessen, Anne A.E. Thorup, Merete Nordentoft, Ole MorsVibeke Bliksted

Medicine

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4 Citations (Scopus)

Abstract

Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year-old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.

Original language	English
Pages (from-to)	195-201
Number of pages	7
Journal	Schizophrenia Research
Volume	246
DOIs	https://doi.org/10.1016/j.schres.2022.06.032
Publication status	Published - Aug 2022

Bibliographical note

Funding Information:
This work was supported by the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) (grant number R248-2017-2003 , R155-2014-1724 , R102-A9118 ), Aarhus University , Aarhus University Hospital Psychiatry, the Mental Health Services of the Capital Region of Denmark and the Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen . The sources of funding had no involvement in the study design, data collection, data analysis, interpretation, writing of the manuscript or decision to submit the manuscript for publication.

Publisher Copyright:
© 2022 The Authors

ASJC Scopus Subject Areas

Psychiatry and Mental health
Biological Psychiatry

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.schres.2022.06.032

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Greve, A. N., Jepsen, J. R. M., Mortensen, E. L., Uher, R., Mackenzie, L., Foldager, L., Gantriis, D., Burton, B. K., Ellersgaard, D., Christiani, C. J., Spang, K. S., Hemager, N., Uddin, J., Henriksen, M. T., Zahle, K. K., Stadsgaard, H., Plessen, K. J., Thorup, A. A. E., Nordentoft, M., ... Bliksted, V. (2022). Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. Schizophrenia Research, 246, 195-201. https://doi.org/10.1016/j.schres.2022.06.032

Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. / Greve, Aja Neergaard; Jepsen, Jens Richardt Møllegaard; Mortensen, Erik Lykke et al.
In: Schizophrenia Research, Vol. 246, 08.2022, p. 195-201.

Research output: Contribution to journal › Article › peer-review

Greve, AN, Jepsen, JRM, Mortensen, EL, Uher, R, Mackenzie, L, Foldager, L, Gantriis, D, Burton, BK, Ellersgaard, D, Christiani, CJ, Spang, KS, Hemager, N, Uddin, J, Henriksen, MT, Zahle, KK, Stadsgaard, H, Plessen, KJ, Thorup, AAE, Nordentoft, M, Mors, O & Bliksted, V 2022, 'Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder', Schizophrenia Research, vol. 246, pp. 195-201. https://doi.org/10.1016/j.schres.2022.06.032

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title = "Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder",

abstract = "Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year-old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.",

author = "Greve, {Aja Neergaard} and Jepsen, {Jens Richardt M{\o}llegaard} and Mortensen, {Erik Lykke} and Rudolf Uher and Lynn Mackenzie and Leslie Foldager and Ditte Gantriis and Burton, {Birgitte Klee} and Ditte Ellersgaard and Christiani, {Camilla Jerlang} and Spang, {Katrine S.} and Nicoline Hemager and Jamal Uddin and Henriksen, {Maria Toft} and Zahle, {Kate Kold} and Henriette Stadsgaard and Plessen, {Kerstin J.} and Thorup, {Anne A.E.} and Merete Nordentoft and Ole Mors and Vibeke Bliksted",

note = "Funding Information: This work was supported by the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) (grant number R248-2017-2003 , R155-2014-1724 , R102-A9118 ), Aarhus University , Aarhus University Hospital Psychiatry, the Mental Health Services of the Capital Region of Denmark and the Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen . The sources of funding had no involvement in the study design, data collection, data analysis, interpretation, writing of the manuscript or decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = aug,

doi = "10.1016/j.schres.2022.06.032",

language = "English",

volume = "246",

pages = "195--201",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

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TY - JOUR

T1 - Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder

AU - Greve, Aja Neergaard

AU - Jepsen, Jens Richardt Møllegaard

AU - Mortensen, Erik Lykke

AU - Uher, Rudolf

AU - Mackenzie, Lynn

AU - Foldager, Leslie

AU - Gantriis, Ditte

AU - Burton, Birgitte Klee

AU - Ellersgaard, Ditte

AU - Christiani, Camilla Jerlang

AU - Spang, Katrine S.

AU - Hemager, Nicoline

AU - Uddin, Jamal

AU - Henriksen, Maria Toft

AU - Zahle, Kate Kold

AU - Stadsgaard, Henriette

AU - Plessen, Kerstin J.

AU - Thorup, Anne A.E.

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Bliksted, Vibeke

N1 - Funding Information: This work was supported by the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) (grant number R248-2017-2003 , R155-2014-1724 , R102-A9118 ), Aarhus University , Aarhus University Hospital Psychiatry, the Mental Health Services of the Capital Region of Denmark and the Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen . The sources of funding had no involvement in the study design, data collection, data analysis, interpretation, writing of the manuscript or decision to submit the manuscript for publication. Publisher Copyright: © 2022 The Authors

PY - 2022/8

Y1 - 2022/8

N2 - Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year-old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.

AB - Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year-old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.

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JO - Schizophrenia Research

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ER -

Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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