TY - JOUR
T1 - Tumor karyotype differentiates lipoblastoma from liposarcoma
AU - Miller, Grant G.
AU - Yanchar, Natalie L.
AU - Magee, J. Fergal
AU - Blair, Geoffrey K.
PY - 1997/12
Y1 - 1997/12
N2 - Lipoblastoma is a rare benign pediatric soft tissue tumor that may be difficult to distinguish from a myxoid liposarcoma clinically or histologically. The authors present a case of a progressively growing, locally invasive soft tissue tumor in a child. Tissue culture of cytogenetic study showed a breakpoint in the long arm of chromosome 8. A review of the literature showed seven case reports of lipoblastoma karyotypes, six of which had a similar breakpoint in chromosome 8. This distinguishes it from the histologically alike myxoid liposarcoma, the karyotype of which typically contains the clonal anomaly t(12;16)(q13:p11). The authors recommend that when performing a biopsy of a childhood adipose tumor with unusual features, such as progressive or invasive growth, that fresh tissue be submitted for cell culture. The tumor karyotype will, in most cases, aid in differentiating lipoblastoma from myxoid liposarcoma.
AB - Lipoblastoma is a rare benign pediatric soft tissue tumor that may be difficult to distinguish from a myxoid liposarcoma clinically or histologically. The authors present a case of a progressively growing, locally invasive soft tissue tumor in a child. Tissue culture of cytogenetic study showed a breakpoint in the long arm of chromosome 8. A review of the literature showed seven case reports of lipoblastoma karyotypes, six of which had a similar breakpoint in chromosome 8. This distinguishes it from the histologically alike myxoid liposarcoma, the karyotype of which typically contains the clonal anomaly t(12;16)(q13:p11). The authors recommend that when performing a biopsy of a childhood adipose tumor with unusual features, such as progressive or invasive growth, that fresh tissue be submitted for cell culture. The tumor karyotype will, in most cases, aid in differentiating lipoblastoma from myxoid liposarcoma.
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U2 - 10.1016/S0022-3468(97)90531-5
DO - 10.1016/S0022-3468(97)90531-5
M3 - Article
C2 - 9434024
AN - SCOPUS:0031467134
SN - 0022-3468
VL - 32
SP - 1771
EP - 1772
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 12
ER -