Tumor karyotype differentiates lipoblastoma from liposarcoma

Grant G. Miller, Natalie L. Yanchar, J. Fergal Magee, Geoffrey K. Blair

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

Lipoblastoma is a rare benign pediatric soft tissue tumor that may be difficult to distinguish from a myxoid liposarcoma clinically or histologically. The authors present a case of a progressively growing, locally invasive soft tissue tumor in a child. Tissue culture of cytogenetic study showed a breakpoint in the long arm of chromosome 8. A review of the literature showed seven case reports of lipoblastoma karyotypes, six of which had a similar breakpoint in chromosome 8. This distinguishes it from the histologically alike myxoid liposarcoma, the karyotype of which typically contains the clonal anomaly t(12;16)(q13:p11). The authors recommend that when performing a biopsy of a childhood adipose tumor with unusual features, such as progressive or invasive growth, that fresh tissue be submitted for cell culture. The tumor karyotype will, in most cases, aid in differentiating lipoblastoma from myxoid liposarcoma.

Original languageEnglish
Pages (from-to)1771-1772
Number of pages2
JournalJournal of Pediatric Surgery
Volume32
Issue number12
DOIs
Publication statusPublished - Dec 1997
Externally publishedYes

ASJC Scopus Subject Areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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