Understanding strategies to improve medication adherence among persons with type 2 diabetes: A scoping review

Michael Vallis, Susie Jin, Agnieszka Klimek-Abercrombie, Andrean Bunko, Atif Kukaswadia, Calum S. Neish, Noah M. Ivers

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Aims: The objectives of this scoping review were to: (1) identify the target audience and contexts in which strategies to improve type 2 diabetes mellitus (T2DM) medication adherence have been used, (2) provide an overview of behaviour change techniques (BCTs) used, (3) describe the determinants of behaviour targeted by strategies and (4) to identify current gaps in strategies. Methods: A systemic search for articles related to T2DM, medication adherence and strategies was conducted in EMBASE, Ovid MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily using the OvidSP platform on 11 March 2021. All publications involving strategies to overcome medication non-adherence among adults with T2DM were included. Strategies were categorized according to the BCT taxonomy and the determinants of behaviour targeted by each strategy were classified by using the Theoretical Domains Framework (TDF). Results: The search identified 58 articles and 61 strategies. The BCT categories Antecedents and Natural consequences and BCTs Feedback on outcome(s) of behaviour, Adding objects to the environment and Information about health consequences were identified most frequently as components of strategies resulting in statistically significant improvement in medication adherence. Strategies targeting the TDF domains Reinforcement and Beliefs about Consequences most often resulted in statistically significant improvements in adherence measures. Conclusions: The findings from this review identify BCTs and targeted behaviours with demonstrated success. Further exploration of the myriad of BCTs and the corresponding determinants of behaviour which were not accessed may be warranted for the development of future strategies to improve medication adherence in type 2 diabetes.

Original languageEnglish
JournalDiabetic Medicine
DOIs
Publication statusAccepted/In press - 2022

Bibliographical note

Funding Information:
The authors thank Benjy Stein from IQVIA for expert librarian advice on developing the search strategy and retrieving articles, Sheily Kamra, Suditi Gogna and Rutuja Mandlik for help with the article screening and data extraction process, and Saurabh Trikha from IQVIA for his assistance with medical writing. Novo Nordisk Canada Inc. provided design, study conduct and financial support for this research, including the interpretation of data. However, each author maintained control over the final content of this manuscript. The publication of study results was not contingent on the sponsor's approval or censorship of the manuscript.

Publisher Copyright:
© 2022 Diabetes UK.

ASJC Scopus Subject Areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

PubMed: MeSH publication types

  • Journal Article
  • Review

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