TY - JOUR
T1 - Update on the Management of Disorders of Sex Development
AU - Romao, Rodrigo L.P.
AU - Pippi Salle, Joao L.
AU - Wherrett, Diane K.
PY - 2012/8
Y1 - 2012/8
N2 - A number of factors have contributed to a sharp increase in the number of publications related to disorders of sex development (DSD) in the past 5 years, namely: the establishment of a consensus in 2006 about nomenclature, investigations and the need to treat these patients in a multidisciplinary setting; increase of the knowledge base about genetic mechanisms of normal and abnormal sex development; critical appraisal about the timing and nature of genital surgery in patients with DSD. Herein, the authors present a comprehensive review with up-to-date data about the approach to the newborn with ambiguous genitalia as well as the diagnosis and management of the most common DSD.
AB - A number of factors have contributed to a sharp increase in the number of publications related to disorders of sex development (DSD) in the past 5 years, namely: the establishment of a consensus in 2006 about nomenclature, investigations and the need to treat these patients in a multidisciplinary setting; increase of the knowledge base about genetic mechanisms of normal and abnormal sex development; critical appraisal about the timing and nature of genital surgery in patients with DSD. Herein, the authors present a comprehensive review with up-to-date data about the approach to the newborn with ambiguous genitalia as well as the diagnosis and management of the most common DSD.
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U2 - 10.1016/j.pcl.2012.05.020
DO - 10.1016/j.pcl.2012.05.020
M3 - Review article
C2 - 22857833
AN - SCOPUS:84864401727
SN - 0031-3955
VL - 59
SP - 853
EP - 869
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
IS - 4
ER -