Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus

Junhong Leng; Leishen Wang; Jing Wang; Weiqin Li; Huikun Liu; Shuang Zhang; Lili Li; Huiguang Tian; Pengcheng Xun; Xilin Yang; Zhijie Yu; Gang Hu

doi:10.1016/j.diabres.2017.09.015

Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus

Junhong Leng, Leishen Wang, Jing Wang, Weiqin Li, Huikun Liu, Shuang Zhang, Lili Li, Huiguang Tian, Pengcheng Xun, Xilin Yang, Zhijie Yu, Gang Hu

Medicine

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Aims To assess the association of uric acid (UA) with the risks of postpartum type 2 diabetes and prediabetes among women with prior gestational diabetes mellitus (GDM). Methods We performed a cross-sectional study of 1262 GDM women at 1–5 years after delivery using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. Logistic regression models were used to estimate the association of different levels of serum UA with the risks of type 2 diabetes and prediabetes. Results The multivariable-adjusted odds ratios (ORs) across quartiles of serum UA were 1.00, 1.23 (95% confidence interval [CI] 0.55–2.78), 2.05 (95% CI 0.96–4.39), and 3.17 (95% CI 1.54–6.55) (P_trend < 0.001) for type 2 diabetes, and 1.00, 1.50 (95% CI 1.03–2.19), 2.28 (95% CI 1.58–3.30), and 2.88 (95% CI 1.99–4.17) (P_trend < 0.001) for prediabetes, respectively. Restricted cubic splines models showed positive linear associations of serum UA as a continuous variable with the risks of type 2 diabetes and prediabetes. This positive association was significant when stratified by healthy weight and overweight participants. Conclusions Serum UA levels have a graded positive association with the risks of type 2 diabetes and prediabetes among Chinese with a history of GDM.

Original language	English
Pages (from-to)	72-79
Number of pages	8
Journal	Diabetes Research and Clinical Practice
Volume	134
DOIs	https://doi.org/10.1016/j.diabres.2017.09.015
Publication status	Published - Dec 2017

Bibliographical note

Funding Information:
This study was supported by Tianjin Women’s and Children’s Health Center, Tianjin Public Health Bureau, European Foundation for the Study of Diabetes ( EFSD )/Chinese Diabetes Society (CDS)/ Lilly programme for Collaborative Research between China and Europe. Dr. Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases ( R01DK100790 ) and the National Institute of General Medical Sciences ( U54GM104940 ) of the National Institutes of Health . We wish to thank the participants in the Tianjin Gestational Diabetes Mellitus Prevention Program and their families, and our Research Group.

Publisher Copyright:
© 2017 Elsevier B.V.

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2017.09.015

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@article{9beb4ef36afa42898c92fc640c400b3b,

title = "Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus",

abstract = "Aims To assess the association of uric acid (UA) with the risks of postpartum type 2 diabetes and prediabetes among women with prior gestational diabetes mellitus (GDM). Methods We performed a cross-sectional study of 1262 GDM women at 1–5 years after delivery using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. Logistic regression models were used to estimate the association of different levels of serum UA with the risks of type 2 diabetes and prediabetes. Results The multivariable-adjusted odds ratios (ORs) across quartiles of serum UA were 1.00, 1.23 (95% confidence interval [CI] 0.55–2.78), 2.05 (95% CI 0.96–4.39), and 3.17 (95% CI 1.54–6.55) (Ptrend < 0.001) for type 2 diabetes, and 1.00, 1.50 (95% CI 1.03–2.19), 2.28 (95% CI 1.58–3.30), and 2.88 (95% CI 1.99–4.17) (Ptrend < 0.001) for prediabetes, respectively. Restricted cubic splines models showed positive linear associations of serum UA as a continuous variable with the risks of type 2 diabetes and prediabetes. This positive association was significant when stratified by healthy weight and overweight participants. Conclusions Serum UA levels have a graded positive association with the risks of type 2 diabetes and prediabetes among Chinese with a history of GDM.",

author = "Junhong Leng and Leishen Wang and Jing Wang and Weiqin Li and Huikun Liu and Shuang Zhang and Lili Li and Huiguang Tian and Pengcheng Xun and Xilin Yang and Zhijie Yu and Gang Hu",

note = "Funding Information: This study was supported by Tianjin Women{\textquoteright}s and Children{\textquoteright}s Health Center, Tianjin Public Health Bureau, European Foundation for the Study of Diabetes ( EFSD )/Chinese Diabetes Society (CDS)/ Lilly programme for Collaborative Research between China and Europe. Dr. Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases ( R01DK100790 ) and the National Institute of General Medical Sciences ( U54GM104940 ) of the National Institutes of Health . We wish to thank the participants in the Tianjin Gestational Diabetes Mellitus Prevention Program and their families, and our Research Group. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = dec,

doi = "10.1016/j.diabres.2017.09.015",

language = "English",

volume = "134",

pages = "72--79",

journal = "Diabetes Research and Clinical Practice",

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T1 - Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus

AU - Leng, Junhong

AU - Wang, Leishen

AU - Wang, Jing

AU - Li, Weiqin

AU - Liu, Huikun

AU - Zhang, Shuang

AU - Li, Lili

AU - Tian, Huiguang

AU - Xun, Pengcheng

AU - Yang, Xilin

AU - Yu, Zhijie

AU - Hu, Gang

N1 - Funding Information: This study was supported by Tianjin Women’s and Children’s Health Center, Tianjin Public Health Bureau, European Foundation for the Study of Diabetes ( EFSD )/Chinese Diabetes Society (CDS)/ Lilly programme for Collaborative Research between China and Europe. Dr. Hu was supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases ( R01DK100790 ) and the National Institute of General Medical Sciences ( U54GM104940 ) of the National Institutes of Health . We wish to thank the participants in the Tianjin Gestational Diabetes Mellitus Prevention Program and their families, and our Research Group. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/12

Y1 - 2017/12

N2 - Aims To assess the association of uric acid (UA) with the risks of postpartum type 2 diabetes and prediabetes among women with prior gestational diabetes mellitus (GDM). Methods We performed a cross-sectional study of 1262 GDM women at 1–5 years after delivery using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. Logistic regression models were used to estimate the association of different levels of serum UA with the risks of type 2 diabetes and prediabetes. Results The multivariable-adjusted odds ratios (ORs) across quartiles of serum UA were 1.00, 1.23 (95% confidence interval [CI] 0.55–2.78), 2.05 (95% CI 0.96–4.39), and 3.17 (95% CI 1.54–6.55) (Ptrend < 0.001) for type 2 diabetes, and 1.00, 1.50 (95% CI 1.03–2.19), 2.28 (95% CI 1.58–3.30), and 2.88 (95% CI 1.99–4.17) (Ptrend < 0.001) for prediabetes, respectively. Restricted cubic splines models showed positive linear associations of serum UA as a continuous variable with the risks of type 2 diabetes and prediabetes. This positive association was significant when stratified by healthy weight and overweight participants. Conclusions Serum UA levels have a graded positive association with the risks of type 2 diabetes and prediabetes among Chinese with a history of GDM.

AB - Aims To assess the association of uric acid (UA) with the risks of postpartum type 2 diabetes and prediabetes among women with prior gestational diabetes mellitus (GDM). Methods We performed a cross-sectional study of 1262 GDM women at 1–5 years after delivery using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. Logistic regression models were used to estimate the association of different levels of serum UA with the risks of type 2 diabetes and prediabetes. Results The multivariable-adjusted odds ratios (ORs) across quartiles of serum UA were 1.00, 1.23 (95% confidence interval [CI] 0.55–2.78), 2.05 (95% CI 0.96–4.39), and 3.17 (95% CI 1.54–6.55) (Ptrend < 0.001) for type 2 diabetes, and 1.00, 1.50 (95% CI 1.03–2.19), 2.28 (95% CI 1.58–3.30), and 2.88 (95% CI 1.99–4.17) (Ptrend < 0.001) for prediabetes, respectively. Restricted cubic splines models showed positive linear associations of serum UA as a continuous variable with the risks of type 2 diabetes and prediabetes. This positive association was significant when stratified by healthy weight and overweight participants. Conclusions Serum UA levels have a graded positive association with the risks of type 2 diabetes and prediabetes among Chinese with a history of GDM.

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Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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