TY - JOUR
T1 - Variations in practices and outcomes of neonates with hypoxic ischemic encephalopathy treated with therapeutic hypothermia across tertiary NICUs in Canada
AU - Canadian Neonatal Network Investigators
AU - Beltempo, Marc
AU - Wintermark, Pia
AU - Mohammad, Khorshid
AU - Jabbour, Elias
AU - Afifi, Jehier
AU - Shivananda, Sandesh
AU - Louis, Deepak
AU - Redpath, Stephanie
AU - Lee, Kyong Soon
AU - Fajardo, Carlos
AU - Shah, Prakesh S.
AU - Lee, Shoo K.
AU - Kanungo, Jaideep
AU - Ting, Joseph
AU - Cieslak, Zenon
AU - Sherlock, Rebecca
AU - Mehrem, Ayman Abou
AU - Toye, Jennifer
AU - Aziz, Khalid
AU - Bodani, Jaya
AU - Strueby, Lannae
AU - Seshia, Mary
AU - Alvaro, Ruben
AU - Mukerji, Amit
AU - Da Silva, Orlando
AU - Augustine, Sajit
AU - Ng, Eugene
AU - Lemyre, Brigitte
AU - Daboval, Thierry
AU - Khurshid, Faiza
AU - Bizgu, Victoria
AU - Barrington, Keith
AU - Lapointe, Anie
AU - Ethier, Guillaume
AU - Drolet, Christine
AU - Piedboeuf, Bruno
AU - Claveau, Martine
AU - St-Hilaire, Marie
AU - Bertelle, Valerie
AU - Masse, Edith
AU - Canning, Roderick
AU - Makary, Hala
AU - Ojah, Cecil
AU - Monterrosa, Luis
AU - Emberley, Julie
AU - Kajetanowicz, Andrzej
N1 - Funding Information:
MB holds an Early Career Investigator Grant from the CIHR Institute of Human Development, Child and Youth Health (IHDCYH), a Research Grant Funding from the FRSQ Clinical Research Scholar Career Award Junior 1, and an Early Career Investigator Grant from the Montreal Children’s Hospital Foundation. This study was supported by a grant from the Canadian Institutes of Health Research (CIHR) funding the Canadian Preterm Birth Network (PBN 150642). PW receives research grant funding from the FRSQ Clinical Research Scholar Career Award Junior 2 and a CIHR Project Grant.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022
Y1 - 2022
N2 - Objective: To characterize variations in practices and outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) across Canadian tertiary Neonatal Intensive Care Units (NICUs). Study design: Retrospective study of neonates admitted for HIE and treated with TH in 24 tertiary NICUs from the Canadian Neonatal Network, 2010–2020. The two primary outcomes of mortality before discharge and MRI-detected brain injury were compared across NICUs using adjusted standardized ratios (SR) with 95% CI. Results: Of the 3261 neonates that received TH, 367 (11%) died and 1033 (37%) of the 2822 with MRI results had brain injury. Overall, rates varied significantly across NICUs for mortality (range 5–17%) and brain injury (range 28–51%). Significant variations in use of inotropes, inhaled nitric oxide, blood products, and feeding during TH were identified (p values < 0.01). Conclusion: Significant variations exist in practices and outcomes of HIE neonates treated with hypothermia across Canada.
AB - Objective: To characterize variations in practices and outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) across Canadian tertiary Neonatal Intensive Care Units (NICUs). Study design: Retrospective study of neonates admitted for HIE and treated with TH in 24 tertiary NICUs from the Canadian Neonatal Network, 2010–2020. The two primary outcomes of mortality before discharge and MRI-detected brain injury were compared across NICUs using adjusted standardized ratios (SR) with 95% CI. Results: Of the 3261 neonates that received TH, 367 (11%) died and 1033 (37%) of the 2822 with MRI results had brain injury. Overall, rates varied significantly across NICUs for mortality (range 5–17%) and brain injury (range 28–51%). Significant variations in use of inotropes, inhaled nitric oxide, blood products, and feeding during TH were identified (p values < 0.01). Conclusion: Significant variations exist in practices and outcomes of HIE neonates treated with hypothermia across Canada.
UR - http://www.scopus.com/inward/record.url?scp=85131680182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131680182&partnerID=8YFLogxK
U2 - 10.1038/s41372-022-01412-7
DO - 10.1038/s41372-022-01412-7
M3 - Article
C2 - 35552529
AN - SCOPUS:85131680182
SN - 0743-8346
JO - Journal of Perinatology
JF - Journal of Perinatology
ER -