Abstract
Objectives: To examine the effects of aging and neuropsychological (NP) impairment on driving simulator performance within a human immunodeficiency virus (HIV)-infected cohort. Methods: Participants included 79 HIV-infected adults (n = 58 > age 50, n = 21 ≤ 40) who completed a NP battery and a personnel computer-based driving simulator task. Outcome variables included total completion time (time) and number of city blocks to complete the task (blocks). Results: Compared to the younger group, the older group was less efficient in their route finding (blocks over optimum: 25.9 [20.1] vs 14.4 [16.9]; P =.02) and took longer to complete the task (time: 1297.6 [577.6] vs 804.4 [458.5] seconds; P =.001). Regression models within the older adult group indicated that visuospatial abilities (blocks: b = -0.40, P <.001; time: b = -0.40, P =.001) and attention (blocks: b = -0.49, P =.001; time: b = -0.42, P =.006) independently predicted simulator performance. The NP-impaired group performed more poorly on both time and blocks, compared to the NP normal group. Conclusions: Older HIV-infected adults may be at risk of driving-related functional compromise secondary to HIV-associated neurocognitive decline.
Original language | English |
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Pages (from-to) | 185-194 |
Number of pages | 10 |
Journal | American Journal of Alzheimer's Disease and other Dementias |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 2013 |
Externally published | Yes |
ASJC Scopus Subject Areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health