What is the Number of Older Canadians Needed to Screen by Measurement of Bone Density to Detect an Undiagnosed Case of Osteoporosis? A Population-Based Study From CaMos

Anna M. Sawka, Alexandra Papaioannou, Robert G. Josse, Timothy M. Murray, George Ioannidis, David A. Hanley, Jerilynn C. Prior, Lehana Thabane, E. A. Papadimitropoulos, Amiram Gafni, Laura Pickard, Tassos Anastassiades, Susan Kirkland, Jonathan D. Adachi, CaMos Research Group the CaMos Research Group

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Routine bone mineral densitometry (BMD) screening has been recommended for women aged ≥ 65 yr (Osteoporosis Canada [OC], International Society for Clinical Densitometry [ISCD], Canadian and United States Task Forces on Preventative Healthcare, and National Osteoporosis Foundation) and for men ≥ 65 yr (OC) or ≥ 70 yr (ISCD). We estimated the number of older Canadians needed to screen (NNS) by BMD to detect an undiagnosed case of osteoporosis, using prospective, multicenter, population-based data from the Canadian Multicentre Osteoporosis Study (CaMos). We included participants aged ≥ 65 yr with baseline dual-energy X-ray absorptiometry (DXA) BMDs at the femoral neck and lumbar spine (L1-L4). Osteoporosis was defined by a T-score ≤ 2.5 at either site. Patients were questioned about a prior diagnosis of osteoporosis. We studied 2699 women and 1032 men aged ≥ 65 yr. The percentage prevalence and 95% confidence intervals were determined. In individuals aged ≥ 65 yr, the prevalence of osteoporosis was 25.6% in women (95% confidence interval, 24.0%, 27.3%) and 8.9% in men (7.3%, 10.8%). In 652 men aged ≥ 70 yr, the prevalence of osteoporosis was 11.3% (9.1%, 14.0%). Of the participants with BMD-defined osteoporosis, 76.6% of woman aged ≥ 65 yr (73.2%, 79.6%; 516 of 674 women), 93.4% of men aged ≥ 65 yr (86.4%, 96.9%; 85 of 91), and 93.2% of men ≥ 70 yr (84.9%, 97.0%; 68 of 73) were not aware of it. Thus, the minimum NNS by BMD testing to detect one previously undiagnosed case of osteoporosis in Canada is: 6 women aged ≥ 65 yr, 13 men aged ≥ 65 yr, and 10 men aged ≥ 70 yr.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalJournal of Clinical Densitometry
Volume9
Issue number4
DOIs
Publication statusPublished - 2006

Bibliographical note

Funding Information:
The CaMos was funded by the Senior's Independence Research Program, through the National Health Research and Development Program of Health Canada (Project No. 6605-4003-OS); The Medical Research Council of Canada; MRC-PMAC Health Program; Merck Frosst Canada Inc.; Eli Lilly Canada Inc.; Procter and Gamble Pharmaceuticals Canada Inc.; Novartis Pharmaceuticals Inc.; Aventis Pharma Inc.; The Dairy Farmers of Canada; and The Arthritis Society. A.M. Sawka is a Canadian Institutes of Health Research new investigator.

ASJC Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

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