White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Eva Gunde; Tomas Novak; Miloslav Kopecek; Matthias Schmidt; Lukas Propper; Pavla Stopkova; Cyril Höschl; Anne Duffy; Martin Alda; Tomas Hajek

doi:10.1016/j.jpsychires.2010.04.019

White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Eva Gunde, Tomas Novak, Miloslav Kopecek, Matthias Schmidt, Lukas Propper, Pavla Stopkova, Cyril Höschl, Anne Duffy, Martin Alda, Tomas Hajek

Medicine

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background: White matter hyperintensities (WMHs) are among the most replicated neuroimaging findings in bipolar disorder (BD). It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, or even represent biological risk factor for BD. Methods: To test whether WMHs meet criteria for an endophenotype of BD, we conducted a high-risk design study and recruited 35 affected, 44 unaffected relatives of bipolar probands (age range 15-30 years), matched by age and sex with 49 healthy controls without any personal or family history of psychiatric disorders. The presence of WMHs was determined from Fluid Attenuated Inversion Recovery (FLAIR) scans acquired on a 1.5. Tesla scanner using a validated semi-quantitative scale. Results: We found mostly low grade WMHs in all groups. The proportion of WMH-positive subjects was comparable between the unaffected high-risk, affected familial and control groups. Conclusion: White matter hyperintensities did not meet criteria for an endophenotype of BD. Bipolar disorder in young subjects without comorbid conditions was not associated with increased rate of WMHs.

Original language	English
Pages (from-to)	76-82
Number of pages	7
Journal	Journal of Psychiatric Research
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.jpsychires.2010.04.019
Publication status	Published - Jan 2011

Bibliographical note

Funding Information:
Supported by NARSAD Young Investigator Award to Dr. Hajek, Dalhousie Clinical Research Scholarship to Dr. Hajek and grant NR8786, from the Internal Grant Agency of Ministry of Health, Czech Republic. None of these granting agencies had any further role in the study design; in the collection, the analysis, and in the interpretation of the data; in the writing of the report; or in the decision to submit the paper for publication.

ASJC Scopus Subject Areas

Psychiatry and Mental health
Biological Psychiatry

PubMed: MeSH publication types

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpsychires.2010.04.019

Cite this

Gunde, E., Novak, T., Kopecek, M., Schmidt, M., Propper, L., Stopkova, P., Höschl, C., Duffy, A., Alda, M., & Hajek, T. (2011). White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study. Journal of Psychiatric Research, 45(1), 76-82. https://doi.org/10.1016/j.jpsychires.2010.04.019

Gunde, E, Novak, T, Kopecek, M, Schmidt, M, Propper, L, Stopkova, P, Höschl, C, Duffy, A, Alda, M & Hajek, T 2011, 'White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study', Journal of Psychiatric Research, vol. 45, no. 1, pp. 76-82. https://doi.org/10.1016/j.jpsychires.2010.04.019

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abstract = "Background: White matter hyperintensities (WMHs) are among the most replicated neuroimaging findings in bipolar disorder (BD). It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, or even represent biological risk factor for BD. Methods: To test whether WMHs meet criteria for an endophenotype of BD, we conducted a high-risk design study and recruited 35 affected, 44 unaffected relatives of bipolar probands (age range 15-30 years), matched by age and sex with 49 healthy controls without any personal or family history of psychiatric disorders. The presence of WMHs was determined from Fluid Attenuated Inversion Recovery (FLAIR) scans acquired on a 1.5. Tesla scanner using a validated semi-quantitative scale. Results: We found mostly low grade WMHs in all groups. The proportion of WMH-positive subjects was comparable between the unaffected high-risk, affected familial and control groups. Conclusion: White matter hyperintensities did not meet criteria for an endophenotype of BD. Bipolar disorder in young subjects without comorbid conditions was not associated with increased rate of WMHs.",

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note = "Funding Information: Supported by NARSAD Young Investigator Award to Dr. Hajek, Dalhousie Clinical Research Scholarship to Dr. Hajek and grant NR8786, from the Internal Grant Agency of Ministry of Health, Czech Republic. None of these granting agencies had any further role in the study design; in the collection, the analysis, and in the interpretation of the data; in the writing of the report; or in the decision to submit the paper for publication. ",

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AU - Stopkova, Pavla

AU - Höschl, Cyril

AU - Duffy, Anne

AU - Alda, Martin

AU - Hajek, Tomas

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N2 - Background: White matter hyperintensities (WMHs) are among the most replicated neuroimaging findings in bipolar disorder (BD). It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, or even represent biological risk factor for BD. Methods: To test whether WMHs meet criteria for an endophenotype of BD, we conducted a high-risk design study and recruited 35 affected, 44 unaffected relatives of bipolar probands (age range 15-30 years), matched by age and sex with 49 healthy controls without any personal or family history of psychiatric disorders. The presence of WMHs was determined from Fluid Attenuated Inversion Recovery (FLAIR) scans acquired on a 1.5. Tesla scanner using a validated semi-quantitative scale. Results: We found mostly low grade WMHs in all groups. The proportion of WMH-positive subjects was comparable between the unaffected high-risk, affected familial and control groups. Conclusion: White matter hyperintensities did not meet criteria for an endophenotype of BD. Bipolar disorder in young subjects without comorbid conditions was not associated with increased rate of WMHs.

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White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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