Role of AEBP1 in the regulation of cholesterol homeostasis, foam cell formation, inflammation and atherogenesis

We are investigating the role of a multifunctional protein known to be involved in the regulation of cell growth and development. The adipocyte enhancer-binding protein (AEBP1) binds DNA and functions as a regulator of gene expression. To elucidate the physiological role of AEBP1, we have generated mice with disruption of AEBP1 gene or targeted over-expression of AEBP1 in macrophages the cell type important in the controlling of cholesterol balance and inflammation. Our recent results suggested that AEBP1 is a potential novel atherogenic factor. In this project, we will establish a direct link of AEBP1 signaling pathways to the pathogenesis of atherosclerosis. Understanding the role AEBP1 plays in atherosclerosis will lead to eventual identification of potential targets that may lead to novel strategies of anti-atherosclerosis therapies.