Structure and dynamics of FAST proteins and peptides by NMR spectroscopy

  • Jakeman, David (PI)
  • Syvitski, Raymond (CoPI)

Proyecto: Proyecto de Investigación

Detalles del proyecto

Description

Our research will determine the structure and dynamics of a variety of proteins and peptides that interact with biological cell membranes providing insight into how these proteins and peptides interact within a membrane environment and which structural features are essential for biological activity. The study of mutant derivatives of these proteins and peptides will enable us to determine structure-activity relationships for these bioactive molecules. We will investigate one class of proteins responsible for causing cell-to-cell fusion, for their unique mechanism of action, and for their role as potential components of a liposome drug delivery system.

EstadoFinalizado
Fecha de inicio/Fecha fin10/1/069/30/09

Financiación

  • Institute of Infection and Immunity: US$ 129.381,00

ASJC Scopus Subject Areas

  • Biochemistry
  • Spectroscopy
  • Infectious Diseases
  • Immunology