β-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn

Bin Zhang, Shiwen Luo, Xian Ping Dong, Xian Zhang, Chunming Liu, Zhenge Luo, Wen Cheng Xiong, Lin Mei

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

81 Citas (Scopus)

Resumen

Agrin is believed to be a factor used by motoneurons to direct acetylcholine receptor (AChR) clustering at the neuromuscular junction. However, exactly how agrin mediates this effect remains unclear. Here we demonstrate that the β-catenin interacts with rapsyn, a molecule key for AChR clustering. Agrin stimulation increases the association of β-catenin with surface AChRs. Suppression of β-catenin expression inhibited agrin-induced AChR clustering, suggesting a necessary role of β-catenin in this event. The β-catenin action did not appear to require the function of T-cell factors (TCFs), suggesting a mechanism independent of TCF-mediated transcription. In contrast, prevention of β-catenin from interacting with α-catenin attenuated agrin-induced AChR clustering. These results suggest that β-catenin may serve as a link between AChRs and α-catenin- associated cytoskeleton, revealing a novel function of β-catenin in synaptogenesis.

Idioma originalEnglish
Páginas (desde-hasta)3968-3973
Número de páginas6
PublicaciónJournal of Neuroscience
Volumen27
N.º15
DOI
EstadoPublished - abr. 11 2007
Publicado de forma externa

ASJC Scopus Subject Areas

  • General Neuroscience

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