β-Cell function or insulin resistance was associated with the risk of type 2 diabetes among women with or without obesity and a history of gestational diabetes

Yuxin Fan, Leishen Wang, Huikun Liu, Shuang Zhang, Huiguang Tian, Yun Shen, Jaakko Tuomilehto, Zhijie Yu, Xilin Yang, Gang Hu, Ming Liu

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

19 Citas (Scopus)

Resumen

Introduction To evaluate the single association of postpartum β-cell dysfunction and insulin resistance (IR), as well as different combinations of postpartum β-cell dysfunction, IR, obesity, and a history of gestational diabetes mellitus (GDM) with postpartum type 2 diabetes risk. Research design and methods The study included 1263 women with prior GDM and 705 women without GDM. Homeostatic model assessment was used to estimate homeostatic model assessment of β-cell secretory function (HOMA-%β) and homeostatic model assessment of insulin resistance (HOMA-IR). Results Multivariable-adjusted ORs of diabetes across quartiles of HOMA-%β and HOMA-IR were 1.00, 1.46, 2.15, and 6.25 (p trend <0.001), and 1.00, 2.11, 5.59, and 9.36 (p trend <0.001), respectively. Women with IR only had the same diabetes risk as women with β-cell dysfunction only. Obesity, together with IR or β-cell dysfunction, had a stronger effect on diabetes risk. This stronger effect was also found for a history of GDM with IR or β-cell dysfunction. Women with three risk factors, including obesity, a history of GDM and β-cell dysfunction/IR, showed the highest ORs of diabetes. Conclusions β-cell dysfunction or IR was significantly associated with postpartum diabetes. IR and β-cell dysfunction, together with obesity and a history of GDM, had the highest ORs of postpartum diabetes risk.

Idioma originalEnglish
Número de artículo001060
PublicaciónBMJ Open Diabetes Research and Care
Volumen8
N.º1
DOI
EstadoPublished - sep. 7 2020

Nota bibliográfica

Funding Information:
Funding This work was supported by the European Foundation for the Study of Diabetes/Chinese Diabetes Society/Lilly program for Collaborative Research between China and Europe. GH was partly supported by the grant from the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100790) and the National Institute of General Medical Sciences (U54GM104940) of the National Institutes of Health. YF and ML were partly supported by the grants from the National Key R&D Programme of China 2019 (YFA 0802502), National Natural Science Foundation of China (81 830 025 and 81620108004), and the Tianjin Municipal Science and Technology Commission (17ZXMFSY00150).

Publisher Copyright:
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

ASJC Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Huella

Profundice en los temas de investigación de 'β-Cell function or insulin resistance was associated with the risk of type 2 diabetes among women with or without obesity and a history of gestational diabetes'. En conjunto forman una huella única.

Citar esto