A Low-Cost Miniature Histotripsy Transducer for Precision Tissue Ablation

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Resumen

A miniature, 10 mm aperture histotripsy transducer with an f-number of 0.7 was fabricated using an elliptically shaped aluminum lens which was epoxy-bonded to an air-backed 5.0 MHz, PTZ-5A, 1-3 dice-and-fill piezoelectric composite, and the lens coupled to water using a quarter-wavelength matching layer of Parylene-C. A KLM model of the device and curved lens was developed. The epoxy layer resulted in an increased power output at 6.8 MHz compared to the 5 MHz composite design. Cavitation was observed in water by driving the composite with a 173 V single-cycle, unipolar 6.8 MHz pulse at a pulse repetition frequency of 50 Hz and a bubble cloud 264 μm long by 124 μm wide was measured. A co-registered imaging and ablation device was also fabricated and characterized. The co-registered device was modified to include a 4 mm x 4 mm square hole through the center, allowing access for a high-frequency imaging array and both imaging and ablation are demonstrated in cerebral tissue with this device. Radial -3 dB beam widths were measured as 0.145 mm and 0.116 mm and axial -3 dB depth of field were 0.698 mm and 0.752 mm for the non-coregistered and co-registered transducers, respectively. Total material cost for the transducer and pulser board are below $200 USD.

Idioma originalEnglish
PublicaciónIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
DOI
EstadoAccepted/In press - sep. 11 2018

Nota bibliográfica

Publisher Copyright:
IEEE

ASJC Scopus Subject Areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

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