A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence

Leslie M. Ogilvie, Brittany A. Edgett, Simon Gray, Sally Al-Mufty, Jason S. Huber, Keith R. Brunt, Jeremy A. Simpson

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and can exceed the magnitude of ventricular pressure during diastole. Accordingly, respiratory pressures may be a confounding factor to assessing cardiac function. While the interaction between respiration and the heart is well characterized, the extent to which systolic and diastolic indices are affected by inspiration is unknown. Our objective was to understand how inspiratory pressure affects the hemodynamic assessment of cardiac function. To do this, we developed custom software to assess and separate indices of systolic and diastolic function into inspiratory, early expiratory, and late expiratory phases of respiration. We then compared cardiac parameters during normal breathing and with various respiratory loads. Variations in inspiratory pressure had a small impact on systolic pressure and function. Conversely, diastolic pressure strongly correlated with negative inspiratory pressure. Cardiac pressures were less affected by respiration during expiration; late expiration was the most stable respiratory phase. In conclusion, inspiration is a large confounding influence on diastolic pressure, but minimally affects systolic pressure. Performing cardiac hemodynamic analysis by accounting for respiratory phase yields more accuracy and analytic confidence to the assessment of diastolic function.

Idioma originalEnglish
Número de artículo17223
PublicaciónScientific Reports
Volumen11
N.º1
DOI
EstadoPublished - dic. 2021

Nota bibliográfica

Funding Information:
This study was supported by Natural Sciences and Engineering Research Council (NSERC), Canadian Institutes of Health Research (CIHR), and Heart and Stroke Foundation of Canada Grants (J. A. Simpson and K. R. Brunt) and Killam Foundation grant (B. A. Edgett). L. M. Ogilvie was supported by an Alexander Graham Bell Canada Graduate Scholarship-Doctoral (CGS D) NSERC.

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus Subject Areas

  • General

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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