A newly recognized hamartomatous syndrome

There are a number of hamartomatous syndromes that remain undelineated to date. We present two children with a remarkably similar pattern of hamartomatous overgrowth that clearly differs from classic neurofibromatosis. The condition is characterized by the continuous appearance of overgrowth of whole areas of the body as well as of specific tissues such as epidermis, fibrous connective tissue, endothelium, fat cells, and bone. Both patients had multiple hamartomas including linear verrucous epidermal nevi, hemangiomas, lipomas, limb overgrowth, plantar overgrowth, hyperostoses, and scleral tumors. It is of interest that two types of lesions, both of mesodermal origin, are distributed in areas of trauma. Fibrous connective tissue overgrowth only occurred in the plantar region. Hyperostoses occurred only on the head and face in areas that could be traumatized by head and face banging.