A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

Veni Bharti, Aseem Bhardwaj, David A. Elias, Arron W.S. Metcalfe, Jong Sung Kim

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

12 Citas (Scopus)

Resumen

Background: Research assessing lipid levels in individuals diagnosed with post-traumatic stress disorder (PTSD) has yielded mixed results. This study aimed to employ meta-analytic techniques to characterize the relationship between the levels of lipid profiles and PTSD. Methods: We performed meta-analyses of studies comparing profiles and levels of lipids between PTSD patients and healthy individuals by searching Embase, Ovid Medline, Scopus, PsycINFO, and Cochrane databases for the studies until March 2021. Meta-analyses were performed using random-effects models with the restricted maximum-likelihood estimator to synthesize the effect size assessed by standardized mean difference (SMD) across studies. Findings: A total of 8,657 abstracts were identified, and 17 studies were included. Levels of total cholesterol (TC) (SMD = 0.57 95% CI, 0.27–0.87, p = 0.003), low-density lipoprotein (LDL) (SMD = 0.48, 95% CI, 0.19–0.76, p = 0.004), and triglyceride (TG) (SMD = 0.46, 95% CI, 0.22–0.70, p = 0.001) were found to be higher, while levels of high-density lipoprotein (HDL) (SMD = –0.47, –0.88 to –0.07, p = 0.026) were found to be lower in PTSD patients compared to healthy controls. Subgroup analysis showed that TG levels were higher in PTSD patients who were on or off of psychotropic medications, both < 40 and ≥ 40 years of age, and having body mass index of < 30 and ≥ 30 compared to healthy controls. Interpretation: This work suggested dysregulation of lipids in PTSD that may serve as biomarker to predict the risk. The study will be useful for physicians considering lipid profiles in PTSD patients to reduce cardiovascular morbidity and mortality.

Idioma originalEnglish
Número de artículo847310
PublicaciónFrontiers in Psychiatry
Volumen13
DOI
EstadoPublished - may. 6 2022

Nota bibliográfica

Funding Information:
This research was conducted with funding from the Mitacs Accelerate Postdoctoral Fellowship, investment from the National Research Council of Canada Industrial Research Assistance Program (NRC-IRAP)—Canadian International Innovation Program (CIIP), and the Scientific Research and Experimental Development (SR&ED) Tax Incentive Program from the Government of Canada.

Publisher Copyright:
Copyright © 2022 Bharti, Bhardwaj, Elias, Metcalfe and Kim.

ASJC Scopus Subject Areas

  • Psychiatry and Mental health

PubMed: MeSH publication types

  • Systematic Review

Huella

Profundice en los temas de investigación de 'A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder'. En conjunto forman una huella única.

Citar esto