Resumen
Retino-recipient cells in the hamster lateral geniculate nucleus project to the suprachiasmatic nucleus via the geniculo-hypothalamic tract (GHT). GHT-ablation alters phase advance shifts to light pulses in a hamster's late subjective night. In this study, the effects of GHT-ablation on wheel-running rhythms of hamsters housed under continuous illumination (LL) were assessed. In the first experiment, hamsters received GHT-ablation or sham surgery while under a light: dark schedule and were subsequently exposed to 250 days of LL. GHT-ablated hamsters showed rhythms with shorter periods and were less likely to show split activity rhythms than sham-operated or partial-lesion controls. In the second experiment, hamsters were housed under LL until rhythms split into two components: hamsters then received either GHT-ablation or sham surgery. Four of seven GHT-ablated hamsters showed re-fusion of their activity pattern into one component, while none of the eight sham-operated animals showed such re-fusion. The results of these two experiments indicate that GHT-ablation alters the responsiveness of the activity rhythm pacemaker to LL exposure.
Idioma original | English |
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Páginas (desde-hasta) | 183-189 |
Número de páginas | 7 |
Publicación | Physiology and Behavior |
Volumen | 42 |
N.º | 2 |
DOI | |
Estado | Published - 1988 |
Nota bibliográfica
Funding Information:We are very grateth\[ to Cathy Legacy-Barrett. Patricia Dickson and Tim Delaney for their skilled technical asfistance. This research was supported by grants from MRC of Canada (MA-8929), NSERC of Canada (A0305) and Dalhousie University RDFS. M. E. Har-rington was supported by a Killam Memorial Scholarship during parl of this study.
ASJC Scopus Subject Areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't