Abnormal stress echocardiography findings in cardiac amyloidosis

Kevin C. Ong, J. Wells Askew, Angela Dispenzieri, Joseph J. Maleszewski, Kyle W. Klarich, Nandan S. Anavekar, Sharon L. Mulvagh, Martha Grogan

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

8 Citas (Scopus)

Resumen

Abstract: Background: Cardiac involvement in immunoglobulin light chain (amyloid light chain, AL) amyloidosis is characterized by myocardial interstitial deposition but can also cause obstructive deposits in the coronary microvasculature. Methods: We retrospectively identified 20 patients who underwent stress echocardiography within 1 year prior to the histologic diagnosis of AL amyloidosis. Only patients with cardiac amyloidosis and no known obstructive coronary disease were included. Results: Stress echocardiograms (13 exercise; 7 dobutamine) were performed for evaluation of dyspnea and/or chest pain. Stress-induced wall motion abnormalities (WMAs) occurred in 11 patients (55%), 4 of whom had normal left ventricular wall thickness. Coronary angiogram was performed in 9 of 11 patients and demonstrated no or mild epicardial coronary artery disease. Seven (54%) patients had an abnormal exercise blood pressure which occurred with similar likelihood between those with and without stress-induced WMAs. Conclusions: Stress-induced WMAs and abnormal exercise blood pressure may occur in patients with cardiac AL amyloidosis despite the absence of significant epicardial coronary artery disease. This finding should raise the possibility of cardiac amyloidosis even in the absence of significant myocardial thickening.

Idioma originalEnglish
Páginas (desde-hasta)124-131
Número de páginas8
PublicaciónAmyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
Volumen23
N.º2
DOI
EstadoPublished - abr. 2 2016
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.

ASJC Scopus Subject Areas

  • Internal Medicine

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