Active surveillance of acute paediatric hospitalisations demonstrates the impact of vaccination programmes and informs vaccine policy in Canada and Australia

IMPACT and PAEDS investigators

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

Sentinel surveillance of acute hospitalisations in response to infectious disease emergencies such as the 2009 influenza A(H1N1)pdm09 pandemic is well described, but recognition of its potential to supplement routine public health surveillance and provide scalability for emergency responses has been limited. We summarise the achievements of two national paediatric hospital surveillance networks relevant to vaccine programmes and emerging infectious diseases in Canada (Canadian Immunization Monitoring Program Active; IMPACT from 1991) and Australia (Paediatric Active Enhanced Disease Surveillance; PAEDS from 2007) and discuss opportunities and challenges in applying their model to other contexts. Both networks were established to enhance capacity to measure vaccine preventable disease burden, vaccine programme impact, and safety, with their scope occasionally being increased with emerging infectious diseases' surveillance. Their active surveillance has increased data accuracy and utility for syndromic conditions (e.g. encephalitis), pathogen-specific diseases (e.g. pertussis, rotavirus, influenza), and adverse events following immunisation (e.g. febrile seizure), enabled correlation of biological specimens with clinical context and supported responses to emerging infections (e.g. pandemic influenza, parechovirus, COVID-19). The demonstrated long-term value of continuous, rather than incident-related, operation of these networks in strengthening routine surveillance, bridging research gaps, and providing scalable public health response, supports their applicability to other countries.

Idioma originalEnglish
Número de artículo1900562
PublicaciónEurosurveillance
Volumen25
N.º24
DOI
EstadoPublished - jun. 2020

Nota bibliográfica

Funding Information:
The PAEDS system was established in 2007 to support Australian compliance with World Health Organization (WHO) AFP surveillance standards as part of polio eradication efforts, and to conduct surveillance for varicella hospitalisations following vaccine introduction and two AEFIs potentially associated with varicella and rotavirus vaccination programmes (seizures and intussusception) (Table 1 and Supplemental Content 1) [13]. PAEDS was funded by the Australian Government as a pilot project in four paediatric hospitals in four states. PAEDS subsequently expanded to seven hospitals in six states and territories, covering around 80% of tertiary paediatric beds. The scope of PAEDS was enlarged over time to provide key evidence regarding vaccine

Funding Information:
The authors gratefully acknowledge the expert assistance of the Monitor Liaisons (Heather Samson, Annick Audet), IMPACT nurse monitors, staff of the IMPACT Data Center (Kim Marty) and Melanie Laffin (Canadian Paediatric Society), as well as the contributions of IMPACT and PAEDS investigators to case identification, reporting and analysis of IMPACT/ PAEDS data, and review of the manuscript.

Funding Information:
IMPACT is supported primarily by federal funding and managed by a non-profit organisation (CPS). This unique arrangement has allowed alternate sources of funding from provincial governments and industry to augment federally funded activities and support additional surveillance targets (e.g. rotavirus), providing stability for the network, while ensuring investigators retain independence in data collection, analysis, and publication.

Publisher Copyright:
© 2020 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

ASJC Scopus Subject Areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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