TY - JOUR
T1 - Acute high-dose sodium selenite administration improves intestinal microcirculation without affecting cytokine release in experimental endotoxemia
AU - Gründling, Matthias
AU - Rickert, Sandra
AU - Saeger, Daniela
AU - Pavlovic, Dragan
AU - Usichenko, Taras
AU - Meissner, Konrad
AU - Wendt, Michael
AU - Hung, Orlando
AU - Murphy, Michael
AU - Whynot, Sara
AU - Lehmann, Christian
PY - 2009/4
Y1 - 2009/4
N2 - We evaluated the effects of acute high-dose sodium selenite (SEL) administration on the intestinal microcirculation and the release of the cytokines TNF-α, IL-1β, IL-6 and IL-10 in experimental endotoxemia (induced by lipopolysaccharide-LPS). Three groups of animals (n=30) were studied: control group, endotoxemic group (15 mg kg-1 i.v. LPS from E. coli) and SEL-treated LPS group (100 μg kg-1 SEL i.v.). SEL treatment resulted in a significant reduced number of firmly adhering leukocytes in intestinal submucosal venules and reduced significantly the impairment of the intestinal functional capillary density. Despite of the improvement of microcirculatory parameters, we did not detect any changes in the pattern of cytokine release. In conclusion, administration of high-dose sodium SEL attenuates leukocyte adhesion and improves capillary perfusion within the intestinal microcirculation without affecting release of the cytokines TNF-α, IL-1β, IL-6 and IL-10 in experimental endotoxemia.
AB - We evaluated the effects of acute high-dose sodium selenite (SEL) administration on the intestinal microcirculation and the release of the cytokines TNF-α, IL-1β, IL-6 and IL-10 in experimental endotoxemia (induced by lipopolysaccharide-LPS). Three groups of animals (n=30) were studied: control group, endotoxemic group (15 mg kg-1 i.v. LPS from E. coli) and SEL-treated LPS group (100 μg kg-1 SEL i.v.). SEL treatment resulted in a significant reduced number of firmly adhering leukocytes in intestinal submucosal venules and reduced significantly the impairment of the intestinal functional capillary density. Despite of the improvement of microcirculatory parameters, we did not detect any changes in the pattern of cytokine release. In conclusion, administration of high-dose sodium SEL attenuates leukocyte adhesion and improves capillary perfusion within the intestinal microcirculation without affecting release of the cytokines TNF-α, IL-1β, IL-6 and IL-10 in experimental endotoxemia.
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U2 - 10.1016/j.jtemb.2008.09.003
DO - 10.1016/j.jtemb.2008.09.003
M3 - Article
C2 - 19398062
AN - SCOPUS:67349171066
SN - 0946-672X
VL - 23
SP - 138
EP - 143
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
IS - 2
ER -