Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study

the CanCOLD Collaborative Research Group, the Canadian Respiratory Research Network

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

40 Citas (Scopus)

Resumen

Rationale: Outdoor air pollution is a potential risk factor for lower lung function and chronic obstructive pulmonary disease (COPD). Little is known about how airway abnormalities and lung growth might modify this relationship. Objectives: To evaluate the associations of ambient air pollution exposure with lung function and COPD and examine possible interactions with dysanapsis. Methods: We made use of cross-sectional postbronchodilator spirometry data from 1,452 individuals enrolled in the CanCOLD (Canadian Cohort Obstructive Lung Disease) study with linked ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) air pollution estimates. Dysanapsis, or the ratio of the airway-to-lung volume calculated from thoracic computed tomography images, was used to examine possible interactions. Measurements and Main Results: In adjusted models, 101.7 ml (95% confidence interval [CI], 2166.2 to 237.2) and 115.0 ml (95% CI, 2196.5 to 233.4) lower FEV1 were demonstrated per increase of 2.4 ug/m3 PM2.5 and 9.2 ppb NO2, respectively. Interaction between air pollution and dysanapsis was not statistically significant when modeling the airway-to-lung ratio as a continuous variable. However, a 109.8 ml (95% CI, 2209.0 to 210.5] lower FEV1 and an 87% (95% CI, 12% to 213%) higher odds of COPD were observed among individuals in the lowest, relative to highest, airway-to-lung ratio, per 2.4 μg/m3 increment of PM2.5. Conclusions: Ambient air pollution exposure was associated with lower lung function, even at relatively low concentrations. Individuals with dysanaptic lung growth might be particularly susceptible to inhaled ambient air pollutants, especially those at the extremes of dysanapsis.

Idioma originalEnglish
Páginas (desde-hasta)44-55
Número de páginas12
PublicaciónAmerican Journal of Respiratory and Critical Care Medicine
Volumen206
N.º1
DOI
EstadoPublished - jul. 1 2022

Nota bibliográfica

Funding Information:
Supported by the Canadian Institutes of Health Research (453225) and GlaxoSmithKline (213021).

Publisher Copyright:
© 2022 by the American Thoracic Society

ASJC Scopus Subject Areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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