Resumen
Binding of CD3-specific antibodies to the TcR-CD3 complex results in T cell activation without the need for occupation of the T cell receptor (TcR) by its ligand. Murine T cells activated in this manner will kill a broad range of tumor targets but not normal lymphoblasts. We report here that non-specific cytolytic activity can be induced in vivo by a single i.p. injection of nonlytic 145-2C11 anti-CD3 monoclonal antibody. At least three populations of effector cells are activated in these mice. These are non-MHC(major histocompatibility complex) restricted cytotoxic T lymphocytes, activated natural killer cells, and lymphokine-activated killer cells. Anti-CD3 treatment is effective in significantly reducing the number of lung tumor nodules which form in mice inoculated with oncogenic ras-transfected syngeneic 10T1/2 fibroblasts. Anti-CD3-activated killer cells may, therefore, find a future role in cancer immunotherapy.
Idioma original | English |
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Páginas (desde-hasta) | 226-230 |
Número de páginas | 5 |
Publicación | Cancer Immunology, Immunotherapy |
Volumen | 29 |
N.º | 3 |
DOI | |
Estado | Published - jul. 1989 |
ASJC Scopus Subject Areas
- Immunology and Allergy
- Immunology
- Oncology
- Cancer Research
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't