TY - JOUR
T1 - An assessment of neurocognitive speed in relation to frailty
AU - Rolfson, Darryl B.
AU - Wilcock, Gordon
AU - Mitnitski, Arnold
AU - King, Elizabeth
AU - De Jager, Celeste A.
AU - Rockwood, Kenneth
AU - Fallah, Nader
AU - Searle, Samuel D.
PY - 2013/3
Y1 - 2013/3
N2 - Objectives: to evaluate the relationship between neurocognitive speed (NCS) and frailty; to consider how this relationship is affected by how frailty is operationalised.Design: secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort. Subjects: of 388 participants who underwent a comprehensive intake assessment followed by an annual follow-up for at least 3 years, data on all measures were available on 164 people. Measurements: NCS was defined as a combined score of <18 on the pattern comparison test (<11 is abnormal) and letter comparison test (<7 is abnormal). Frailty was defined from a modified Phenotype model, the Edmonton Frailty Scales (EFS) and a frailty index (FI); the latter two were adapted here to exclude cognitive measures. Results: in multivariate logistic (NCS as < or ≤18) and linear regression (NCS as continuous variable), only the FI (OR = 0.87) was significant (P < 0.05). When all frailty measures were included in the multivariate analysis only, FI (OR = 0.88) was significant (P < 0.05). Mini-mental Status Examination remained significantly related to NCS throughout all analysis. Conclusion: NCS slows with increasing frailty as shown with the FI.
AB - Objectives: to evaluate the relationship between neurocognitive speed (NCS) and frailty; to consider how this relationship is affected by how frailty is operationalised.Design: secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort. Subjects: of 388 participants who underwent a comprehensive intake assessment followed by an annual follow-up for at least 3 years, data on all measures were available on 164 people. Measurements: NCS was defined as a combined score of <18 on the pattern comparison test (<11 is abnormal) and letter comparison test (<7 is abnormal). Frailty was defined from a modified Phenotype model, the Edmonton Frailty Scales (EFS) and a frailty index (FI); the latter two were adapted here to exclude cognitive measures. Results: in multivariate logistic (NCS as < or ≤18) and linear regression (NCS as continuous variable), only the FI (OR = 0.87) was significant (P < 0.05). When all frailty measures were included in the multivariate analysis only, FI (OR = 0.88) was significant (P < 0.05). Mini-mental Status Examination remained significantly related to NCS throughout all analysis. Conclusion: NCS slows with increasing frailty as shown with the FI.
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U2 - 10.1093/ageing/afs185
DO - 10.1093/ageing/afs185
M3 - Article
C2 - 23296141
AN - SCOPUS:84874520753
SN - 0002-0729
VL - 42
SP - 191
EP - 196
JO - Age and Ageing
JF - Age and Ageing
IS - 2
ER -