An inhibitory action of histamine on the rat isolated vas deferens

M. M. Vohra

doi:10.1016/0306-3623(79)90079-X

An inhibitory action of histamine on the rat isolated vas deferens

M. M. Vohra

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

1. 1. In rat vas deferens histamine concentrations from 0.2 to 650 μM depressed twitch response to field stimulation in a dose-related manner, but did not evoke release of [³H]NA. The depression was greatest at low stimulation frequency. 2. 2. Histamine only slightly depressed contractile response to exogenously added noradrenaline. However, reduction of Ca²⁺ concentration to 1 mM produced a marked dose-related decrease in contractile response. 3. 3. Cimetidine, but not mepyramine, reduced or abolished histamine inhibition of twitch response and contractile response to added noradrenaline in the presence of 1 mM Ca²⁺-containing Krebs. 4. 4. These findings demonstrate the presence of a post-synaptic inhibitory histamine H₂-receptor in the rat vas deferens.

Idioma original	English
Páginas (desde-hasta)	405-409
Número de páginas	5
Publicación	Vascular Pharmacology
Volumen	10
N.º	5
DOI	https://doi.org/10.1016/0306-3623(79)90079-X
Estado	Published - 1979

Nota bibliográfica

Funding Information:
Acknowledgements--I wish to thankM rs. Virginia Miller for her excellentte chnicaal ssistancaen d Dr. E. C. Vos of Smith,K line & FrenchL aboratoriesM, ontrealQ, uebec, Canadafo r generouslsyu pplyingth ec imetidineT.h e work was supportedb y a grant from the Medical Research Council of Canada.

ASJC Scopus Subject Areas

Pharmacology

PubMed: MeSH publication types

Journal Article

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@article{219396f99daf4b8e83f190de379dfc67,

title = "An inhibitory action of histamine on the rat isolated vas deferens",

abstract = "1. 1. In rat vas deferens histamine concentrations from 0.2 to 650 μM depressed twitch response to field stimulation in a dose-related manner, but did not evoke release of [3H]NA. The depression was greatest at low stimulation frequency. 2. 2. Histamine only slightly depressed contractile response to exogenously added noradrenaline. However, reduction of Ca2+ concentration to 1 mM produced a marked dose-related decrease in contractile response. 3. 3. Cimetidine, but not mepyramine, reduced or abolished histamine inhibition of twitch response and contractile response to added noradrenaline in the presence of 1 mM Ca2+-containing Krebs. 4. 4. These findings demonstrate the presence of a post-synaptic inhibitory histamine H2-receptor in the rat vas deferens.",

author = "Vohra, {M. M.}",

note = "Funding Information: Acknowledgements--I wish to thankM rs. Virginia Miller for her excellentte chnicaal ssistancaen d Dr. E. C. Vos of Smith,K line & FrenchL aboratoriesM, ontrealQ, uebec, Canadafo r generouslsyu pplyingth ec imetidineT.h e work was supportedb y a grant from the Medical Research Council of Canada.",

year = "1979",

doi = "10.1016/0306-3623(79)90079-X",

language = "English",

volume = "10",

pages = "405--409",

journal = "Vascular Pharmacology",

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number = "5",

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T1 - An inhibitory action of histamine on the rat isolated vas deferens

AU - Vohra, M. M.

N1 - Funding Information: Acknowledgements--I wish to thankM rs. Virginia Miller for her excellentte chnicaal ssistancaen d Dr. E. C. Vos of Smith,K line & FrenchL aboratoriesM, ontrealQ, uebec, Canadafo r generouslsyu pplyingth ec imetidineT.h e work was supportedb y a grant from the Medical Research Council of Canada.

PY - 1979

Y1 - 1979

N2 - 1. 1. In rat vas deferens histamine concentrations from 0.2 to 650 μM depressed twitch response to field stimulation in a dose-related manner, but did not evoke release of [3H]NA. The depression was greatest at low stimulation frequency. 2. 2. Histamine only slightly depressed contractile response to exogenously added noradrenaline. However, reduction of Ca2+ concentration to 1 mM produced a marked dose-related decrease in contractile response. 3. 3. Cimetidine, but not mepyramine, reduced or abolished histamine inhibition of twitch response and contractile response to added noradrenaline in the presence of 1 mM Ca2+-containing Krebs. 4. 4. These findings demonstrate the presence of a post-synaptic inhibitory histamine H2-receptor in the rat vas deferens.

AB - 1. 1. In rat vas deferens histamine concentrations from 0.2 to 650 μM depressed twitch response to field stimulation in a dose-related manner, but did not evoke release of [3H]NA. The depression was greatest at low stimulation frequency. 2. 2. Histamine only slightly depressed contractile response to exogenously added noradrenaline. However, reduction of Ca2+ concentration to 1 mM produced a marked dose-related decrease in contractile response. 3. 3. Cimetidine, but not mepyramine, reduced or abolished histamine inhibition of twitch response and contractile response to added noradrenaline in the presence of 1 mM Ca2+-containing Krebs. 4. 4. These findings demonstrate the presence of a post-synaptic inhibitory histamine H2-receptor in the rat vas deferens.

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UR - http://www.scopus.com/inward/citedby.url?scp=0018673295&partnerID=8YFLogxK

U2 - 10.1016/0306-3623(79)90079-X

DO - 10.1016/0306-3623(79)90079-X

M3 - Article

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AN - SCOPUS:0018673295

SN - 0306-3623

VL - 10

SP - 405

EP - 409

JO - Vascular Pharmacology

JF - Vascular Pharmacology

IS - 5

ER -

An inhibitory action of histamine on the rat isolated vas deferens

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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