An interactive triple-helical collagen builder

Jan K. Rainey; M. Cynthia Goh

doi:10.1093/bioinformatics/bth247

An interactive triple-helical collagen builder

Jan K. Rainey, M. Cynthia Goh

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

91 Citas (Scopus)

Resumen

Summary: To facilitate the building of triple-helical polypeptide structures, we provide an interactive, platform-independent Tcl/Tk script. User specified amino acid sequences are parsed to obtain localized melting temperature estimates corresponding to helical propensity. These propensities may be graphically examined prior to their automated use in combination with two separate statistical parameter sets to build the complete polypeptide backbone and, if desired, predict side-chain terminal atom locations.

Idioma original	English
Páginas (desde-hasta)	2458-2459
Número de páginas	2
Publicación	Bioinformatics
Volumen	20
N.º	15
DOI	https://doi.org/10.1093/bioinformatics/bth247
Estado	Published - oct. 12 2004
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
We thank Robert Boyko at PENCE for helpful discussions regarding Tcl/Tk, Darren Anderson at U of T for beta-testing and the reviewers for useful suggestions. J.K.R. is grateful for an Alberta Heritage Foundation for Medical Research Postdoctoral Fellowship and for the use of PENCE computers during script development.

ASJC Scopus Subject Areas

Statistics and Probability
Biochemistry
Molecular Biology
Computer Science Applications
Computational Theory and Mathematics
Computational Mathematics

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author = "Rainey, {Jan K.} and Goh, {M. Cynthia}",

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N2 - Summary: To facilitate the building of triple-helical polypeptide structures, we provide an interactive, platform-independent Tcl/Tk script. User specified amino acid sequences are parsed to obtain localized melting temperature estimates corresponding to helical propensity. These propensities may be graphically examined prior to their automated use in combination with two separate statistical parameter sets to build the complete polypeptide backbone and, if desired, predict side-chain terminal atom locations.

AB - Summary: To facilitate the building of triple-helical polypeptide structures, we provide an interactive, platform-independent Tcl/Tk script. User specified amino acid sequences are parsed to obtain localized melting temperature estimates corresponding to helical propensity. These propensities may be graphically examined prior to their automated use in combination with two separate statistical parameter sets to build the complete polypeptide backbone and, if desired, predict side-chain terminal atom locations.

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An interactive triple-helical collagen builder

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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