Anatomical and neurochemical organization of the serotonergic system in the mammalian brain and in particular the involvement of the dorsal raphe nucleus in relation to neurological diseases

Harry W.M. Steinbusch, Mohammad Amin Dolatkhah, David A. Hopkins

Producción científica: Capítulo en Libro/Reporte/Acta de conferenciaCapítulo

29 Citas (Scopus)

Resumen

The brainstem is a neglected brain area in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, frontotemporal lobar degeneration and autonomic dysfunction. In Depression, several observations have been made in relation to changes in one particular the Dorsal Raphe Nucleus (DRN) which also points toward as key area in various age-related and neurodevelopmental diseases. The DRN is further thought to be related to stress regulated processes and cognitive events. It is involved in neurodegeneration, e.g., amyloid plaques, neurofibrillary tangles, and impaired synaptic transmission in Alzheimer's disease as shown in our autopsy findings. The DRN is a phylogenetically old brain area, with projections that reach out to a large number of regions and nuclei of the central nervous system, particularly in the forebrain. These ascending projections contain multiple neurotransmitters. One of the main reasons for the past and current interest in the DRN is its involvement in depression, and its main transmitter serotonin. The DRN also points toward the increased importance and focus of the brainstem as key area in various age-related and neurodevelopmental diseases. This review describes the morphology, ascending projections and the complex neurotransmitter nature of the DRN, stressing its role as a key research target into the neural bases of depression.

Idioma originalEnglish
Título de la publicación alojada5-HT Interaction with Other Neurotransmitters
Subtítulo de la publicación alojadaExperimental Evidence and Therapeutic Relevance - Part B
EditoresGiuseppe Di Giovanni, Giuseppe Di Giovanni, Philippe De Deurwaerdere
EditorialElsevier B.V.
Páginas41-81
Número de páginas41
ISBN (versión impresa)9780444642585
DOI
EstadoPublished - ene. 2021

Serie de la publicación

NombreProgress in Brain Research
Volumen261
ISSN (versión impresa)0079-6123
ISSN (versión digital)1875-7855

Nota bibliográfica

Publisher Copyright:
© 2021 Elsevier B.V.

ASJC Scopus Subject Areas

  • General Neuroscience

PubMed: MeSH publication types

  • Journal Article
  • Review

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