Resumen
Objectives: To investigate the relation between metastatic potential of salivary adenoid cystic carcinoma (SACC) and tumor cell-platelet adhesion, and the antimetastatic effect of integrin IIb/IIIa inhibitor on SACC. Methods: Tumor cell-platelet adhesion of highly metastatic SACC-LM, non-highly metastatic SACC-83 and effect of aspirin, arginine-aspartate (RD), magnesium acetylsalicylate on adhesion were studied in vitro. Antimetastafic effect of aspirin, RD, magnesium acetysalicylate on experimental metastasis of SACC was observed in vivo. Results: The tumor cell-platelet adhesion was stronger in SACC-LM than in SACC-83. Aspirin, RD and magnesium acetylsalicylate could inhibit the adhesion of SACC-LM at the concentration of 1, 5 and 25 μg/ml. RD can inhibit experimental metastasis of SACC. Conclusion: Metastasis of SACC is related to platelet-tumor cell adhesion, RD could inhibit metastasis of SACC.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 198-201 |
| Número de páginas | 4 |
| Publicación | Chinese Journal of Cancer Research |
| Volumen | 13 |
| N.º | 3 |
| DOI | |
| Estado | Published - 2001 |
Nota bibliográfica
Funding Information:Received date: January 11, 2001; Accepted date: June 20, 2001 Foundation item: The work was supported by the National Natural Science Foundation of China (No. 39270723). *Author to whom correspondence should be addressed. Phone: (0086-10)-62173402; Fax: (0086-10)-62173402; E-mail: OMS7 @s pace.beij.ihw, com.cn Biography: LI Feng-he (1964-), attending physician, doctor of medicine, now works at Bethune International Peace Hospital, majors in stomatology, especially in maxillofacial surgery.
ASJC Scopus Subject Areas
- Oncology
- Cancer Research
ODS de las Naciones Unidas
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