Resumen
Chronic exposure to inorganic arsenic and trace metals has been linked to prostate cancer, and altered arsenic methylation capacity may have an important role in arsenic carcinogenesis. Biomarkers may be able to elucidate this role. Our objectives were to characterize profiles of arsenic species and metallome in toenails and urine samples, compare profiles between prostate cancer cases and controls, and determine the discriminant ability of toenail and urine biomarkers. Toenail samples (n = 576), urine samples (n = 152), and questionnaire data were sourced from the Atlantic Partnership for Tomorrow's Health (PATH) cohort study. Healthy controls were matched to prostate cancer cases (3:1 ratio) on sex, age, smoking status, and the province of residence. Metallome profiles and proportions of arsenic species were measured in toenail and urine samples. Analysis of covariance (ANCOVA) was used to compare the mean percent monomethylarsonic acid (%MMA), dimethylarsonic acid (%DMA), inorganic arsenic (%iAs), primary methylation index (PMI, MMA/iAs), and secondary methylation index (SMI, DMA/MMA). Multivariate analysis of covariance (MANCOVA) was used to compare selected metal concentrations. Mean %MMA was significantly lower and SMI was significantly higher in toenails from prostate cancer cases compared to controls in unadjusted and adjusted models. Proportions of arsenic species were correlated with total arsenic in toenails. Arsenic speciation in urine was not different between cases and controls, nor were metallome profiles in toenails and urine. Our results indicate that toenails are a viable biomarker for altered arsenic speciation in prostate cancer cases and may have greater utility than urine in this context.
| Idioma original | English |
|---|---|
| Número de artículo | 818069 |
| Publicación | Frontiers in Public Health |
| Volumen | 10 |
| DOI | |
| Estado | Published - jul. 7 2022 |
Nota bibliográfica
Funding Information:We would like to thank the Atlantic PATH participants who donated their time, personal health history, and biological samples to this project. We would also like to thank the Atlantic PATH team members for data collection and management and Health and Environments Research Center (HERC) Laboratory member, Sydney Kenney for her assistance with sample preparation for analysis. We are grateful to Dr. Anthony Reiman of the University of New Brunswick for his assistance in project administration.
Funding Information:
This research was conducted using Atlantic PATH data and biosamples, under application 2018-102 with funding from the Canadian Cancer Society (CCS grant #705566), the New Brunswick Health Research Foundation (NBHRF), Nova Scotia Health Authority (NSHA), and Beatrice Hunter Cancer Research Institute (BHCRI). The data used in this research were made available by the Atlantic PATH study, which is the Atlantic Canada regional component of the CanPath funded by the Canadian Partnership Against Cancer and Health Canada.
Publisher Copyright:
Copyright © 2022 Keltie, Hood, Cui, Sweeney, Ilie, Adisesh, Dummer, Bharti and Kim.
ASJC Scopus Subject Areas
- Public Health, Environmental and Occupational Health
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
