TY - JOUR
T1 - Automated versus manual control of inspired oxygen to target oxygen saturation in preterm infants
T2 - A systematic review and meta-analysis
AU - Mitra, Souvik
AU - Singh, Balpreet
AU - El-Naggar, Walid
AU - McMillan, Douglas D.
N1 - Publisher Copyright:
© 2017 Nature America, Inc., part of Springer Nature.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objectives: To conduct a systematic review of clinical trials comparing automated versus manual fraction of inspired oxygen (FiO 2 ) control to target oxygen saturation (SpO 2 ) in preterm infants. Design: The authors searched MEDLINE, Embase, CENTRAL, and CINAHL from inception upto December 2016, reviewed conference proceedings and sought results of unpublished trials. Studies were included if automated FiO 2 control was compared to manual control in preterm infants on positive pressure respiratory support. The primary outcome was percentage of time spent within the target SpO 2 range. Summary mean differences (MD) were computed using random effects model. Results: Out of 276 identified studies 10 met the inclusion criteria. Automated FiO 2 control significantly improved time being spent within the target SpO 2 range [MD: 12.8%; 95% CI: 6.5-19.2%; I 2 = 90%]. Periods of hyperoxia (MD:-8.8%; 95% CI: -15 to -2.7%), severe hypoxia(SpO 2 < 80%)(MD: -0.9%;95%CI: -1.5 to -0.4%) and hypoxic events (MD: -5.6%; 95% CI: -9.1 to -2.1%) were significantly reduced with automated control. Conclusion: Automated FiO 2 adjustment provides significant improvement of time in target saturations, reduces periods of hyperoxia, and severe hypoxia in preterm infants on positive pressure respiratory support.
AB - Objectives: To conduct a systematic review of clinical trials comparing automated versus manual fraction of inspired oxygen (FiO 2 ) control to target oxygen saturation (SpO 2 ) in preterm infants. Design: The authors searched MEDLINE, Embase, CENTRAL, and CINAHL from inception upto December 2016, reviewed conference proceedings and sought results of unpublished trials. Studies were included if automated FiO 2 control was compared to manual control in preterm infants on positive pressure respiratory support. The primary outcome was percentage of time spent within the target SpO 2 range. Summary mean differences (MD) were computed using random effects model. Results: Out of 276 identified studies 10 met the inclusion criteria. Automated FiO 2 control significantly improved time being spent within the target SpO 2 range [MD: 12.8%; 95% CI: 6.5-19.2%; I 2 = 90%]. Periods of hyperoxia (MD:-8.8%; 95% CI: -15 to -2.7%), severe hypoxia(SpO 2 < 80%)(MD: -0.9%;95%CI: -1.5 to -0.4%) and hypoxic events (MD: -5.6%; 95% CI: -9.1 to -2.1%) were significantly reduced with automated control. Conclusion: Automated FiO 2 adjustment provides significant improvement of time in target saturations, reduces periods of hyperoxia, and severe hypoxia in preterm infants on positive pressure respiratory support.
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U2 - 10.1038/s41372-017-0037-z
DO - 10.1038/s41372-017-0037-z
M3 - Article
C2 - 29296004
AN - SCOPUS:85039838187
SN - 0743-8346
VL - 38
SP - 351
EP - 360
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -