Birth prevalence studies of the Crouzon syndrome: comparison of direct and indirect methods

M. Michael Cohen, Sven Krelborg

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

148 Citas (Scopus)

Resumen

Cohen Jr MM, Kreiborg S. Birth prevalence studies of the Crouzon syndrome: comparison of direct and indirect methods. Clin Genet 1992: 41: 12–15. An indirect method for estimating the birth prevalence of the Crouzon syndrome is presented. The fraction of Crouzon syndrome patients in large clinical surveys of all cases of craniosynostosis is calculated and the fractional component obtained is multiplied by the known birth prevalence of craniosynostosis in general. Crouzon syndrome makes up approximately 4.8% of all cases of craniosynostosis. Using a weighted average estimate, birth prevalence was calculated to be 16.5/1 000 000. The results of the indirect method compare favorably with those obtained by the direct method. Nevertheless, because the indirect method is based on a number of assumptions that are easily violated, we cannot recommend its general use except under special circumstances.

Idioma originalEnglish
Páginas (desde-hasta)12-15
Número de páginas4
PublicaciónClinical Genetics
Volumen41
N.º1
DOI
EstadoPublished - ene. 1992

ASJC Scopus Subject Areas

  • Genetics
  • Genetics(clinical)

PubMed: MeSH publication types

  • Journal Article

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