TY - JOUR
T1 - BK virus nephropathy in a heart transplant recipient
T2 - Case report and review of the literature
AU - Barber, C. E.H.
AU - Hewlett, T. J.C.
AU - Geldenhuys, L.
AU - Kiberd, B. A.
AU - Acott, P. D.
AU - Hatchette, T. F.
PY - 2006/6
Y1 - 2006/6
N2 - The human polyomavirus BK virus (BKV) remains latent in the urinary tract and may be reactivated in immunocompromised states. BKV is noted to be the etiologic agent of polyomavirus-associated nephropathy (PVAN), which is a significant cause of allograft failure in renal transplant patients. Renal dysfunction following non-renal solid organ transplantation is common and is typically attributed to drug toxicity or patient comorbidities. In this article we describe a case of PVAN in the native kidneys of a heart transplant recipient and review the literature. Although this is only the fourth case reported, BKV nephropathy should be considered in the differential diagnosis of new renal failure following non-kidney solid organ transplantation, as early diagnosis of PVAN is necessary to prevent irreversible renal damage.
AB - The human polyomavirus BK virus (BKV) remains latent in the urinary tract and may be reactivated in immunocompromised states. BKV is noted to be the etiologic agent of polyomavirus-associated nephropathy (PVAN), which is a significant cause of allograft failure in renal transplant patients. Renal dysfunction following non-renal solid organ transplantation is common and is typically attributed to drug toxicity or patient comorbidities. In this article we describe a case of PVAN in the native kidneys of a heart transplant recipient and review the literature. Although this is only the fourth case reported, BKV nephropathy should be considered in the differential diagnosis of new renal failure following non-kidney solid organ transplantation, as early diagnosis of PVAN is necessary to prevent irreversible renal damage.
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U2 - 10.1111/j.1399-3062.2006.00163.x
DO - 10.1111/j.1399-3062.2006.00163.x
M3 - Article
C2 - 16734635
AN - SCOPUS:33744800546
SN - 1398-2273
VL - 8
SP - 113
EP - 121
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
IS - 2
ER -