Botulinum toxin injections into salivary glands to decrease oral secretions in CHARGE syndrome: Prospective case study

Kim D. Blake, Jillian Maccuspie, Gerard Corsten

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

CHARGE syndrome is a genetic disorder caused by a mutation in the CHD7 gene on chromosome 8. Major clinical diagnostic criteria for this heterogeneous disorder include ocular coloboma, choanal atresia/stenosis, characteristic external and internal ear abnormalities, and cranial nerve abnormalities. Patients with CHARGE syndrome often have dysphagia and are at high risk for aspiration of both upper and lower gastrointestinal secretions. The following case-report describes the use of Botulinum toxin A (Botox) to reduce excess salivary secretions in a ventilator dependant infant who would have required a tracheotomy. Thereafter, Botox was used regularly (4-5 months) to decrease the salivary secretions. This case-report is unique in that it describes the intermittent and prospective use of Botox to reduce excess salivary secretions and prevent the resulting aspiration-related complications in an infant with CHARGE syndrome.

Idioma originalEnglish
Páginas (desde-hasta)828-831
Número de páginas4
PublicaciónAmerican Journal of Medical Genetics, Part A
Volumen158 A
N.º4
DOI
EstadoPublished - abr. 2012
Publicado de forma externa

ASJC Scopus Subject Areas

  • Genetics
  • Genetics(clinical)

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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